It’s no secret that carbs—especially refined ones like sugary cereals, white bread and pasta, or sweet drinks—cause your blood sugar to spike and dip. So it makes sense that eating less of them can help keep things nice and even. For healthy people, this can translate to more steady energy, less brain fog, and fewer sugary cravings, Mancinelli explains.


You can approach keto in a number of different ways. On some keto diets, like dirty keto, it doesn’t matter where your fats, protein, and carbs come from. So dinner could be a bunless cheeseburger with extra bacon. Eating bad fats like low-quality vegetable oils, packaged low-carb snacks, and processed cheese dials up inflammation, making weight loss more challenging.[8]
The American Diabetes Association (ADA) just put out a position paper on treating diabetes. It’s focus on treatment and prevention, especially for the increasing incidents of diabetes 2 among youth, demonstrates the willful ignorance of institutions that create medical standards for the medical profession. What is ignored is the potential for treating obesity and diabetes 2 with the high-fat low-carb ketogenic diet, which has proven effective for all the factors leading to diabetes and diabetes 2 itself, even improving the overall health of those afflicted with diabetes 1, the less frequent form of diabetes that requires insulin injections.
First reported in 2003, the idea of using a form of the Atkins diet to treat epilepsy came about after parents and patients discovered that the induction phase of the Atkins diet controlled seizures. The ketogenic diet team at Johns Hopkins Hospital modified the Atkins diet by removing the aim of achieving weight loss, extending the induction phase indefinitely, and specifically encouraging fat consumption. Compared with the ketogenic diet, the modified Atkins diet (MAD) places no limit on calories or protein, and the lower overall ketogenic ratio (about 1:1) does not need to be consistently maintained by all meals of the day. The MAD does not begin with a fast or with a stay in hospital and requires less dietitian support than the ketogenic diet. Carbohydrates are initially limited to 10 g per day in children or 20 g per day in adults, and are increased to 20–30 g per day after a month or so, depending on the effect on seizure control or tolerance of the restrictions. Like the ketogenic diet, the MAD requires vitamin and mineral supplements and children are carefully and periodically monitored at outpatient clinics.[48]
Hello, I am doing IF 16:8 & my eating window is in the evening. I’m confused as to what to eat during those 8 hours. I’ve been eating 1 meal & a snack. Is this enough? I’ve been doing Keto dieting for 6 months. Initially lost 5 #. (Realize it was water #) Now I weigh more than I ever have, as of today!! Drink loads of water, eat healthy fats, mod protein & limited carbs, non processed. Can you help? Thanks!! 

Excessive ketone bodies can produce a dangerously toxic level of acid in the blood, called ketoacidosis. During ketoacidosis, the kidneys begin to excrete ketone bodies along with body water in the urine, causing some fluid-related weight loss. Ketoacidosis most often occurs in individuals with type 1 diabetes because they do not produce insulin, a hormone that prevents the overproduction of ketones. However in a few rare cases, ketoacidosis has been reported to occur in nondiabetic individuals following a prolonged very low carbohydrate diet. [4,5]
My advice is to keep your food plan in balance—eat mostly vegetables (about 1-2 pounds per day), eat the minimum protein to preserve lean body mass, avoid processed foods and those that inflame you, and track your body composition over time. Extreme works for some people, but not for me, and not for all women. I prefer getting into ketosis via intermittent fasting, on a 16/8 protocol.

Commonly known as “keto”, a ketogenic diet is a diet typically characterized by a 4:1 ratio of dietary fat to protein and carbohydrate and was originally used in the treatment of childhood epilepsy. It has been theorized that keto diets facilitate greater fat loss in humans as an absence of dietary carbohydrate forces the body to oxidize fat as its primary energy source.
Although the patients underwent a total of 10 visits, the complete body composition analyses were synchronized with the ketone levels in 4 visits (Table 1; Fig. 1). Visit C-1 was the baseline visit, before starting the diet, with no ketosis (0.0 ± 0.1 mmol/L) and a body weight of 95.9 ± 16.3 kg. Visit C-2 was at the time of maximum level of ketosis (1.0 ± 0.6 mmol/L) with a body weight of 84.2 ± 18.0 kg. At visit C-3 (after 89.7 ± 19.1 days of VLCK), patients began the return to a normal diet and showed a reduction in ketone levels (0.7 ± 0.5 mmol/L) and a body weight of 76.6 ± 11.1 kg. Finally, at visit C-4, the patients were out of ketosis (0.2 ± 0.1 mmol/L) and showed a body weight of 75.1 ± 11.8 kg. All weights were statistically different from baseline levels (P < 0.05; Table 1; Fig. 1).
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Though technically a fruit, avocados offer a rich source of heart-healthy monounsaturated fatty acids (MUFAs). They're also packed with fiber to bolster digestive health. One-half of an avocado contains 161 calories, 2 grams (g) of protein, 15 g of fat, 9 g of total carbs, and 7 g of fiber (bringing it to 2 g of net carbs), notes the U.S. Department of Agriculture (USDA).

“I have been working as an internal medicine doctor and diabetologist for over 20 years, focusing on gestational diabetes mellitus (GDM), and also teaching future doctors and nutritionists. In 2016, we corrected our official dietary guidelines for GDM, removing the minimum recommended intake of carbohydrates and setting a maximum at 200 grams a day, with low-carbohydrate diets as an option. I would like to thank GDM dietitian Lily Nichols, Dr. Andreas Eenfeldt at Diet Doctor and the entire LCHF community for improving outcomes of Czech women with GDM and other patients with type 1 and type 2 diabetes or metabolic syndrome.”
A final guideline: Even if you’re keto, portions of fat still matter, says Jill Keene, RDN, in White Plains, New York. “How much you specifically eat depends on your calorie needs and goals, but overconsuming fat can cause weight gain,” she says. Also, considering fat is your body’s main fuel source on a keto diet, she advises spreading out your fats evenly throughout the day.
Research indicates that diets that are high in fat, like the keto diet, do not have a negative impact on cholesterol and triglycerides as long as the carbohydrate intake remains very low. In fact, your cholesterol and triglycerides might actually improve, if you're focusing on eating healthy fats like avocado, olive oil and nuts, not loading up on bacon and burgers.
36. NCD Risk Factor Collaboration (NCD-RisC) Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: A pooled analysis of 2416 population-based measurement studies in 128.9 million children, adolescents, and adults. Lancet. 2017;390:2627–2642. doi: 10.1016/S0140-6736(17)32129-3. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
Some previous studies have suggested that very-low-calorie ketogenic (VLCK) diets may be effective tools to manage overweight and obesity (10, 11, 13). VLCK diets are a nutritional intervention that emulate fasting by restricting carbohydrates and fat with a relative increase in protein intake (6). The increased protein content may be partially responsible for the muscle mass preservation (12–14). Importantly, the weight-reducing action of these diets is rapid, and despite the fact that the ketosis state lasts only 60 to 90 days at the start of treatment, the weight reduction remains for up to 2 years (13). Therefore, VLCK diets operate by potent mechanisms to induce weight loss, and various body compartments might be altered. To the best of our knowledge, no studies have exhaustively assessed the changes in body composition associated with this type of diet, and variations in muscle strength have been only assessed in athletes (15).

In summary, the LCKD had positive effects on body weight, waist measurement, serum triglycerides, and glycemic control in a cohort of 21 participants with type 2 diabetes. Most impressive is that improvement in hemoglobin A1c was observed despite a small sample size and short duration of follow-up, and this improvement in glycemic control occurred while diabetes medications were reduced substantially in many participants. Future research must further examine the optimal medication adjustments, particularly for diabetes and diuretic agents, in order to avoid possible complications of hypoglycemia and dehydration. Because the LCKD can be very effective at lowering blood glucose, patients on diabetes medication who use this diet should be under close medical supervision or capable of adjusting their medication.
Given this new meta-analysis, it’s safe to say that low-carb and high-carb diets with protein matched have similar effects on energy expenditure and body fatness. However, this doesn’t mean that the insulin theory of obesity is entirely wrong — these results simply suggest that the theory carries much less significance than calorie intake in general.
“As a board certified physician practicing internal and obesity medicine, I reclaimed my health and lost over 150 pounds by ignoring conventional medical advice. I now focus on diabetes, hypertension and lipid management through lifestyle and dietary modifications whenever possible. As well as seeing patients in my clinic, I provide remote consultations via tele-medicine software and equipment, utilizing remotely-tracked bio-impedance scales, blood pressure cuffs and continuous glucose monitoring devices.”
Dinner: In a small sauce pan bring 2-3 cups of water to the boil. Cook a large egg in rolling boil for 5 minutes, then transfer to ice bath (a bowl with cold water and ice cubes in it). Wash and spin dry butter lettuce, top with sliced avocado and hemp seed. Serve soft boiled egg with cherry tomatoes, butter lettuce salad and mayonnaise as dressing.
All of the patients followed a VLCK diet according to a commercial weight loss program (PNK Method), which includes lifestyle and behavioral modification support. The intervention included an evaluation by the specialist physician conducting the study and assessment by an expert dietician. All patients underwent a structured program of physical exercise with external supervision (16). This method is based on high-biological-value protein preparations obtained from cow milk, soya, avian eggs, green peas, and cereals. Each preparation contained 15 g protein, 4 g carbohydrates, 3 g fat, and 50 mg docosahexaenoic acid, and provided 90 to 100 kcal (16).
If you're doing everything else right but missing these elements, you'll stall your progress. Getting subpar sleep, not moving enough, and environmental toxins are among the factors that can stall weight loss even when you're vigilantly following a keto diet. What you eat matters, but how you live also dramatically affects weight loss. For many patients, dialing up sleep, reducing environmental and psychological stressors, and incorporating high-intensity burst training can be big needle movers to overcome plateaus.
Option 3: "Make your own keto 'lunchable' with cubes of grilled chicken, a slice of nitrate-free ham, cheese cubes, pickle slices, a hard-boiled egg, a few raw grape tomatoes, raw veggies like cauliflower or broccoli, a few almonds or walnuts, guacamole, and ranch dressing," says Stefanski. (Looking for something meat-free? Here are 29 Vegetarian Keto Recipes for Plant-Based Eaters.)
8. Van Lenten, B. J., Hama, S. Y., De Beer, F. C., Stafforini, D. M., McIntyre, T. M., Prescott, S. M., … Navab, M. (1995). Anti-inflammatory HDL becomes pro-inflammatory during the acute phase response. Loss of protective effect of HDL against LDL oxidation in aortic wall cell cocultures. Journal of Clinical Investigation, 96(6), 2758–2767. PMID: 8675645
Excessive ketone bodies can produce a dangerously toxic level of acid in the blood, called ketoacidosis. During ketoacidosis, the kidneys begin to excrete ketone bodies along with body water in the urine, causing some fluid-related weight loss. Ketoacidosis most often occurs in individuals with type 1 diabetes because they do not produce insulin, a hormone that prevents the overproduction of ketones. However in a few rare cases, ketoacidosis has been reported to occur in nondiabetic individuals following a prolonged very low carbohydrate diet. [4,5]

One theory is that an extreme increase in cholesterol may be common in those undergoing rapid weight loss. This is because the fat cells we have stored in our adipose tissue contain high amounts of both triglycerides and cholesterol. When we begin to break down our stored fat to be metabolized for energy, cholesterol in the blood goes up temporarily.

Carbohydrates have been linked to this skin condition, so cutting down on them may help. And the drop in insulin that a ketogenic diet can trigger may also help stop acne breakouts. (Insulin can cause your body to make other hormones that bring on outbreaks.) Still, more research is needed to determine exactly how much effect, if any, the diet actually has on acne. 


Constipation is a common side effect of low-carb eating plans, including the ketogenic diet. Severely curbing your carb intake means saying goodbye to high-fiber foods like whole grains, beans, and a large proportion of fruits and vegetables, says Ginger Hultin, MS, RDN, Seattle-based nutritionist and spokesperson for the Academy of Nutrition and Dietetics.
Motivation Monday! No matter where you are starting this journey from, I promise you the destination is worth it. When I first started Keto I was at my wits end. I was sick all the time, I had no energy, my emotions were everywhere, I hated my body, and I felt like I had tried everything to fix it but nothing worked. Keto is more then just for weight loss, it’s for overall health. I’m no longer burdened with a disease I dealt with for years, my energy levels are always high, my emotions have levelled, and now when I look in the mirror I’m proud. I’m not going to sit here and tell you guys that it was easy because it wasn’t. But it was so so so worth it. ⠀⠀⠀⠀⠀⠀⠀⠀⠀ ⠀⠀⠀⠀⠀⠀⠀⠀⠀ ⠀⠀⠀⠀⠀⠀⠀ ⠀⠀⠀⠀⠀⠀⠀⠀⠀ ⠀⠀ ⠀⠀⠀⠀⠀⠀⠀⠀⠀ .⠀⠀⠀⠀⠀⠀⠀⠀⠀ If you guys are struggling to get going and have questions, or just need help staying on track, give me a call! Im a certified Ketogenic Nutrition consultant (with a real diploma and everything 😝) and I’d love to meet with you! - - - - #keto #ketoer #ketosis #ketofit #ketodiet #lchf #lchfdiet #ketogenic #ketogains #ketogenicdiet #ketogeniclife #ketoworks #ketofollow #ketogeniclifestyle #ketoaf #fatadapted #kcko #bodybybacon #ketoyyc #ketocanada #ketoweightlossjourney #ketoweightloss #ketoweightlosstransformation #yycfit #yycfitfam
A keto diet works for almost anyone since you can be vegan or vegetarian and still achieve ketogenesis. As a rule of thumb, focus on foods that are naturally high in fat and avoid highly processed foods that are labeled with trans-fats as much as possible. Eat fruits that are low on the glycemic index but are still rich in fiber and, eat other foods like avocados (also for the fat) and berries. Additionally, eat lots of green, yellow and red vegetables.

You should then transition to a normalized set of macros. While keto dieting can be good for short term fat loss, it’s important that it not brainwash you into thinking that certain foods or macros are “bad”. Eating a balanced diet with an understanding of your total daily energy expenditure (TDEE) is the healthiest way to eat and the most sustainable way to lose weight long term.
In conclusion, to the best of our knowledge, this is the first study that exhaustively assessed food and alcohol cravings and changes in well-being determinants, such as sexual function, physical activity, and sleep abnormalities and QoL, during the weight-reduction process induced by a VLCK diet. The severe weight loss induced by the VLCK diet-PNK method was concomitant with a decrease in food and alcohol cravings, increases in physical activity, reduction of sleep abnormalities, and improvement in sexual functioning. Overall, these psychobiological parameters were translated to an enhancement in general QoL for the dieters. Relevantly, this is the first study able to distinguish the effect of ketosis per se independently of the weight-loss magnitude because the strongest effect was evidenced at highly ketosis-mild weight reduction, rather than at nonketosis-strong (mean 20 kg) weight reduction. Therefore, the results of this study evidenced that the rapid and sustained weight and FM loss induced by VLCK-diet are associated with good food control and improvements in the psychological well-being parameters in obese subjects that could be reinforced by the effect of ketosis. This effect could contribute to long-term success of this therapy and further reinforce the suitability of a VLCK-diet as a viable and valuable treatment option for obesity.
I used an online keto calculator to set a goal for calories, carbs and fat. I mostly followed the suggestions, with the exception of fat. The calculator suggested over 200 grams of fat each day. That's tough to hit without loading ghee into my coffee or swigging some coconut oil before lunch. Can it be done? Absolutely. I just couldn't get there. For me, the focus was on reducing carbs. I let the other pieces just fall into place.
“I have an interest in diabetes and preventative medicine and have started recommending intermittent fasting in combination with a low-carb, high-fat diet to all of my patients both for treatment and reversal of diabetes and general good health and prevention. I recommend the Diet Doctor website to all of my patients so they can find the best information from knowledgeable experts regarding living a low-carb lifestyle, from educational videos to amazing recipes and everything in between.”
–Make healthy breakfast fun with these little low carb blueberry pancake dippers. They're easy enough to make on a weekday morning! This post is sponsored by Wyman's. Do you get into a breakfast rut? You wake up, wander to the kitchen, grab a cup of coffee and think...same old same old. You could have eggs...again. Or you could have a low carb muffin...again. Maybe you have some low carb bread on hand for toast...again. Whatever your breakfast routine, you're sick of it and you want something different. Yep, this happens in my house too, with relative frequency.All Day I Dream About Food

“I recommend low-carbohydrate, high-fat (ketogenic) diets to almost all my patients to improve their quality of life. The LCHF diet reduces inflammation, promotes weight loss, and improves blood biomarkers without prescription agents. The result is improved sleep, sharper mental clarity, more energy throughout the day, and healthier relationships to food. Most patients suffer “fat phobia” but fat does not make you fat! Sugar does! We teach patients to eat lots of healthy fats and cycle in and out of ketosis. We refer everyone to Diet Doctor as a great resource, especially for the carb contents of various food and drinks.”

I prescribe nutritional ketosis for my patients with brain and focus issues, such as: epilepsy, attention deficit, brain fog, traumatic brain injury, memory issues, mild cognitive impairment, Parkinson’s disease, and Alzheimer’s disease (including patients with one or two copies of the genes for Alzheimer’s, called ApoE4). Most of my patients on keto say they feel smarter, sharper, and more focused—and some may lose weight (fat) as a result of using ketones as fuel.
Hi Danielle, yes, most Keto Recipes I’ve seen on social media don’t look very appealing to me either. I have a Keto Breakfast Casserole and a Green Smoothie on the blog you can use the search bar in the menu, just enter “keto” and they’ll all appear. I am also working on a 21-Day Keto Challenge e-book at the moment. If you’re interested in being notified when it’s ready I recommend signing up for my newsletter, safest way to not miss it.

“As a Diplomate of the American Board of Clinical Lipidology, I help my patients decrease their risk of diabetes, heart disease, stroke, and Alzheimer’s disease. Intermittent fasting, low-carb, high-fat (LCHF) diets, and ketogenic diets have powerful effects on adiposopathy, arterial inflammation, and endothelial dysfunction. Patients often come to me for a consultation because they have developed an extremely high LDL-P while on a ketogenic diet. We work together to improve their lipid profile by optimizing their nutrition and lifestyle using a personalized, integrative approach.”
The biggest shifts in your daily habits will be how you food shop and how you cook, and recipes that are ketogenic need to be followed rather than just low-carb. You will require the healthy fats in order to get into ketosis and have enough energy without the carbs. And you will be considerably more energetic and healthier when cooking your own keto-friendly food rather than buying supposedly keto foods off the shelf.
We have a super supportive group of “squeakers” over on Facebook who love helping newbies with questions and cheering on everyone’s weight loss progress and Non Scale Victories (NSV’s). Join us over there and see the radical results the SCKC is having on so many people!  And stay tuned for my new book Squeaky Clean Keto – which will include over 120 new SCKC and Whole 30 friendly recipes, and at least 4 weeks of new meal plans!
“The totality of evidence is very clear: A low-carbohydrate dietary approach is the most effective way to manage the insulin resistance syndrome which is that single biggest driver of obesity, type 2 diabetes and cardiovascular disease. Diet Doctor has been instrumental in providing extremely useful, clear and educational material to all who want to implement this dietary approach in to their lives. That’s why I recommend the website to all my at-risk patients.”
Participants completed take-home food records (4 consecutive days, including a weekend) collected at baseline and at weeks 2, 8, and 16 during the study. Participants were given handouts with examples of how to complete the records. A registered dietician analyzed the food records using a nutrition software program (Food Processor SQL, ESHA Research, Inc., Salem, OR).

If any of your numbers are significantly different from what is listed, there may be deeper underlying health issues to be addressed. These are things that can be great to work on with a functional medicine or nutrition practitioner to find the root of your issues. You can get a comprehensive idea of your cholesterol and inflammation levels with our Complete Thyroid Report.


“I am a hospitalist/primary care doctor and also a specialist in obesity. As I see it, nutrition and other lifestyle factors are at the root of most of the diseases I treat. My own health issues corrected with LCHF. I went on to recommend LCHF to my patients, who have since experienced a wide variety of improved outcomes. Face-to-face time with patients is frustratingly short so simply writing “DietDoctor.com” on slip of paper and handing it to patients is a great way to set them in the direction of trustworthy diet information.”
The one important caveat: Eating keto also ups the risk for diabetic ketoacidosis, a life-threatening condition where fat gets broken down too fast and causes the blood to become acidic. It’s much more common in people with type 1 diabetes, but if you have type two and are eating keto, talk with your doctor about what you should be doing to diminish your risk.
Dinner: In a small sauce pan bring 2-3 cups of water to the boil. Cook a large egg in rolling boil for 5 minutes, then transfer to ice bath (a bowl with cold water and ice cubes in it). Wash and spin dry butter lettuce, top with sliced avocado and hemp seed. Serve soft boiled egg with cherry tomatoes, butter lettuce salad and mayonnaise as dressing.
Some negative side effects of a long-term ketogenic diet have been suggested, including increased risk of kidney stones and osteoporosis, and increased blood levels of uric acid (a risk factor for gout). Possible nutrient deficiencies may arise if a variety of recommended foods on the ketogenic diet are not included. It is important to not solely focus on eating high-fat foods, but to include a daily variety of the allowed meats, fish, vegetables, fruits, nuts, and seeds to ensure adequate intakes of fiber, B vitamins, and minerals (iron, magnesium, zinc)—nutrients typically found in foods like whole grains that are restricted from the diet. Because whole food groups are excluded, assistance from a registered dietitian may be beneficial in creating a ketogenic diet that minimizes nutrient deficiencies.
What's more, it's especially important to make sure your diet is well-planned when you're eating keto-style, because the foods you can choose from are limited. In addition to checking in with a dietitian if you're able, Stefanski recommends that you "talk to your doctor and make sure she or he is aware that you'll be starting a diet that completely changes how your body metabolizes energy." You might also want to check your most recent bloodwork levels for things such as cholesterol, vitamin D, and other indicators of health because these can change while on keto. That's because for some people, a prolonged keto diet can result in certain nutritional deficiencies or even high cholesterol. But most experts will tell you that the ketogenic diet is not a permanent lifestyle change (as could be the case for something like the 80/20 approach to eating or a Mediterranean eating style).
All of the patients followed a VLCK diet according to a commercial weight loss program (PNK Method), which includes lifestyle and behavioral modification support. The intervention included an evaluation by the specialist physician conducting the study and assessment by an expert dietician. All patients underwent a structured program of physical exercise with external supervision (16). This method is based on high-biological-value protein preparations obtained from cow milk, soya, avian eggs, green peas, and cereals. Each preparation contained 15 g protein, 4 g carbohydrates, 3 g fat, and 50 mg docosahexaenoic acid, and provided 90 to 100 kcal (16).
A randomized control study in 2017 examined the effects of a ketogenic diet combined with Crossfit training on body composition and performance. Results from this study concluded that subjects following a low-carbohydrate ketogenic diet (LCKD) significantly decreased body weight, body fat percentage and fat mass compared to those in the control group[*].
The fatal flaw in this reasoning is that we don’t have the same energy expenditure as our fat mass increases. I just want to point out that the calories in/calories out system don’t claim to predict exact energy expenditure, weight gain, or weight loss. It’s just a system that shows how energy intake and expenditure are linked with energy storage and energy loss for the average person.
The PSQI questionnaire is a clinical sleep-behavior questionnaire that has been validated for use in patients with insomnia, cancer, Parkinson’s disease, and the general population [30]. The questionnaire is designed to assess indexes of sleep during the preceding month and contains 19 questions that use Likert scales from 0–3. All questions are categorized into the following 7 subvariables: duration of sleep, sleep disturbance, sleep latency, day dysfunction because of sleepiness, sleep efficiency, subjective sleep quality, and use of a sleeping medication. Each of these 7 variables is scored between 0 and 3 arbitrary units (au), which generates a summed total score of 0–21 au. This total score is termed the global sleep score (GSS) with >5 au associated with a poor sleep condition and ≤5 au associated with a good sleep condition.
Kristin Parker is an American temporarily living in South Korea. Her role with Team Diet Doctor is customer service. If you have a question or a comment on our social media platforms, website or our Facebook group, she will likely be the one to answer you back! Kristin cooks for a family of four, including two hungry teenage sons. Her keto meal plan yields generous servings of substantial, hearty meals that they all like.
In 1921, Rollin Turner Woodyatt reviewed the research on diet and diabetes. He reported that three water-soluble compounds, β-hydroxybutyrate, acetoacetate, and acetone (known collectively as ketone bodies), were produced by the liver in otherwise healthy people when they were starved or if they consumed a very low-carbohydrate, high-fat diet.[10] Dr. Russell Morse Wilder, at the Mayo Clinic, built on this research and coined the term "ketogenic diet" to describe a diet that produced a high level of ketone bodies in the blood (ketonemia) through an excess of fat and lack of carbohydrate. Wilder hoped to obtain the benefits of fasting in a dietary therapy that could be maintained indefinitely. His trial on a few epilepsy patients in 1921 was the first use of the ketogenic diet as a treatment for epilepsy.[10]
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