Early studies reported high success rates; in one study in 1925, 60% of patients became seizure-free, and another 35% of patients had a 50% reduction in seizure frequency. These studies generally examined a cohort of patients recently treated by the physician (a retrospective study) and selected patients who had successfully maintained the dietary restrictions. However, these studies are difficult to compare to modern trials. One reason is that these older trials suffered from selection bias, as they excluded patients who were unable to start or maintain the diet and thereby selected from patients who would generate better results. In an attempt to control for this bias, modern study design prefers a prospective cohort (the patients in the study are chosen before therapy begins) in which the results are presented for all patients regardless of whether they started or completed the treatment (known as intent-to-treat analysis).[19]
The classic ketogenic, or “keto,” diet calls for consuming a low amount of carbs, a high amount of fat, and a moderate amount of protein. But in the current study, participants induced ketosis by getting the majority of their calories from protein, a small amount from fat, and a low amount from carbs. One of the side effects of very low-calorie diets is loss of lean muscle mass, but on the adjusted keto diet in the study, participants preserved lean muscle mass. Researchers attributed the preservation of lean muscle mass to participants’ sustained RMR, and their results support those of a prior study, published in February 2017 in the Journal of Clinical Endocrinology and Metabolism.
I am a stage four kidney disease patient. I am also a type one diabetic. I have had diabetes for 37 years. My Internist suggested the Keto diet for me, but there are so many if the foods on the Keto diet that I’m not able to eat because of my kidneys functioning at 22%. How do I reconcile this diet plan to work with my kidney disease? I’m not allowed any dairy, because of my high potassium. Is almond milk ok to drink? I’m not allowed avocados, mushrooms, spinach, tomatoes, greens, (beet or chard). No bacon, or pork. No melons, bananas, oranges, peaches, pears, some apples, pineapple. I can have berries of all kinds. will this still work for me?
The modern obesity epidemic appears to be an unprecedented phenomenon, and it coincides with an ever-increased focus on counting calories. Correlation is not causation, so it would obviously be wrong to say that obesity is caused by counting calories. However, counting calories appears to be, at best, an imperfect aid to weight control. So what is really going on?
“I encourage my patients to do fasting coupled with a very-low-carbohydrate, whole-foods diet because of the astounding biochemical and clinical improvements these interventions provide, in terms of managing chronic metabolic illnesses like diabetes, hypertension, and obesity. I invite my patients to go to Diet Doctor because it is a very reliable source of information for people following a low-carbohydrate diet.”
In order to transition and remain in this state, aiming for about 30–50 net grams is typically the recommended amount of total carbs to start with. This is considered a more moderate or flexible approach but can be less overwhelming to begin with. Once you’re more accustomed to “eating keto,” you can choose to lower carbs even more if you’d like (perhaps only from time to time), down to about 20 grams of net carbs daily. This is considered the standard, “strict” amount that many keto dieters aim to adhere to for best results, but remember that everyone is a bit different.
Fanatic? Someone with T2D, a disease usually claimed to be progressive and a never ending stream of problems and medications, was REVERSED. That’s something to shout from the rooftops. The drop in medication use alone, but the big pharma companies would prefer that people’s stories of reversing (well, putting it into remission) T2D get called fanatical instead of insightful.
Here’s encouragement…it’s not all about weight in the beginning. As you ween off of sugar (which is really poison to your body), your body has to start getting rebooted. I had a solid week or more of serious detox. I knew that getting the poison out of my body was going to be significant, and it was. Don’t be discouraged. It’s well worth it to truly rid your gut and body of cancer-causing poison, not to mention your ability to fight disease. The acid level will change. Your arthritis (joints) will improve. Stick with it and don’t give up. Your family is worth it!
“I recommend low-carb nutrition for the majority of my patients and clients. And I send them all to Diet Doctor for the best recipes, instructional videos and written guides for everything someone needs to get started and to thrive on a low-carb lifestyle. Diet Doctor doesn’t have anything to sell you; its only goal is to provide you with the highest quality, evidence-based information to help you improve your life. That is hard to find in today’s ad-driven and product-driven internet. In fact, I loved Diet Doctor so much, I decide to work for them hosting their podcast!”
An extreme form of low-carbohydrate diet – the ketogenic diet – is established as a medical diet for treating epilepsy.[14] Through celebrity endorsement it has become a popular weight-loss fad diet, but there is no evidence of any distinctive benefit for this purpose, and it had a number of side effects.[14] The British Dietetic Association named it one of the "top 5 worst celeb diets to avoid in 2018".[14]
In spite of the scientific evidence and real-life testimonials, not everyone is recommended to go on the ketosis diet. This highly specialized, extremely meticulous diet plan is suited to a particular dieter profile, and may also be harmful to some without the guidance of a doctor. But if performed correctly, the very low-calorie diet may be the only way for you to experience considerable, life-changing weight reduction.

Requires an adaptation process. Getting keto adapted can take one to two weeks and the transition can be uncomfortable for some people. The “Keto Flu” is commonly used to describe flu-like symptoms associated with the transition process: headaches, fatigue, nausea, etc. Due to restricted carb intake, your body is not retaining as much water so loss of electrolytes is common. This can easily be rectified with taking mineral supplements or exogenous ketones, such as the beta hydroxybutyrate mineral salts in KetoLogic® BHB [16].
The ketogenic diet is a medical nutrition therapy that involves participants from various disciplines. Team members include a registered paediatric dietitian who coordinates the diet programme; a paediatric neurologist who is experienced in offering the ketogenic diet; and a registered nurse who is familiar with childhood epilepsy. Additional help may come from a medical social worker who works with the family and a pharmacist who can advise on the carbohydrate content of medicines. Lastly, the parents and other caregivers must be educated in many aspects of the diet for it to be safely implemented.[5]
Keto flu is a real thing. Cutting your carbs to the bone and going into a state of ketosis (where your body burns fat for energy) can bring on a cluster of uncomfortable symptoms, such as headaches, fatigue, muscle aches, nausea, and diarrhea. The side effects are the result of your body transitioning to using fat as its primary source of energy instead of carbs, explains Kristen Mancinelli, MS, RDN, author of The Ketogenic Diet. Once it adapts to the new fuel source (usually within a week or two), you’ll start to feel better.
A final guideline: Even if you’re keto, portions of fat still matter, says Jill Keene, RDN, in White Plains, New York. “How much you specifically eat depends on your calorie needs and goals, but overconsuming fat can cause weight gain,” she says. Also, considering fat is your body’s main fuel source on a keto diet, she advises spreading out your fats evenly throughout the day.

Keep low-carb, high-fat dipping sauces, such as salad dressings and flavored mayonnaise, handy when you’re eating. They’re an easy way to boost your total fat—the second most important nutrient to track after net carb totals—and they add flavor and creamy satisfaction to many proteins and dinners, from grilled pork chops to lamb burgers. Now that you’re an expert on how to make the perfect keto diet menu, check out these unexpected health benefits of the keto diet.
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Participants met with researchers 10 times over a four-month period. During 4 of the 10 visits, researchers analyzed participants’ blood and body fat for changes in body weight, hormones, ketone bodies (which are produced during ketosis), and muscle losses. After 60 to 90 days, participants were gradually taken off ketosis and placed on a low-calorie diet consisting of between 800 and 1,500 calories per day, and then a maintenance diet consisting of 1,500 and 2,000 calories, depending on the participant. Out of the 20 participants enrolled in the study, 12 completed the regimen and lost about 44.5 pounds each.
“I have been working as an internal medicine doctor and diabetologist for over 20 years, focusing on gestational diabetes mellitus (GDM), and also teaching future doctors and nutritionists. In 2016, we corrected our official dietary guidelines for GDM, removing the minimum recommended intake of carbohydrates and setting a maximum at 200 grams a day, with low-carbohydrate diets as an option. I would like to thank GDM dietitian Lily Nichols, Dr. Andreas Eenfeldt at Diet Doctor and the entire LCHF community for improving outcomes of Czech women with GDM and other patients with type 1 and type 2 diabetes or metabolic syndrome.”
Which leads us to your personality. You need to be VERY strong willed to follow this diet. It follows very strict rules and you need to be able to commit to this. It makes it hard to eat out with friends or eat with friends in general. It’s hard to find food that fits this diet in common restaurants, but and this takes us to the next point, your health goals might be more important.

A very recent review on nutritional approaches toward preventing and reversing Alzheimer’s disease (AD) was conducted in Christchurch, New Zealand’s Canterbury University. The results were submitted to the journal Nutrition. It’s title: "The ketogenic diet as a potential treatment and prevention strategy for Alzheimer's disease." After analyzing 33 studies researching AD and other neurological disorders handled with a ketogenic diet and supplementing coconut oil, the University of Canterbury review analysis concluded: "In this review, we hypothesize that the ketogenic diet could be an effective treatment and prevention for Alzheimer's disease, but both ketone production and carbohydrate restriction may be needed to achieve this."
Diet is the most important lifestyle factor for weight loss. In order to effect significant loss of weight it is necessary to create a consistent caloric deficit. This has the rather obvious side effect of leaving individuals feeling hungry and as though they are in a constant state of deprivation. Dieting is based upon this basic concept, which is the most likely reason why dieting is very likely to fail in the long-term. The ketogenic diet, while controversial and a highly polarizing subject, has demonstrated promise as an alternative dietary strategy for weight management. The KD may hold an advantage over traditional calorie-restricted diets, in that nutritional ketosis may enhance appetite control, and subsequently improve dietary adherence and long-term success. Nevertheless, the KD should be approached with caution, as there are both short- and long-term potential negative side effects. More research into this unique dietary strategy is warranted to fully investigate all potentially positive and negative aspects.

Hello, following a Keto diet with IF but cholesterol ratios not proper. Diet fats come mainly from olive oil, avocado oil, once a week beef, no butter, bacon etc. Had to go back on statins. Goal is stay away from drugs. Is there a doctor/clinic in the Boston area that you can recommend that understands/tests what you explain in this article? Please advise.
Minerals/Electrolytes: Adopting a ketogenic diet will change the way your body uses (and loses) certain minerals. Not replacing these minerals can lead to symptoms of the “keto flu” such as lightheadedness, headaches, constipation, muscle cramps and fatigue. Refer to this article for tips on how to replace common minerals such as sodium, potassium, magnesium and calcium.

Because it lacks carbohydrates, a ketogenic diet is rich in proteins and fats. It typically includes plenty of meats, eggs, processed meats, sausages, cheeses, fish, nuts, butter, oils, seeds, and fibrous vegetables. Because it is so restrictive, it is really hard to follow over the long run. Carbohydrates normally account for at least 50% of the typical American diet. One of the main criticisms of this diet is that many people tend to eat too much protein and poor-quality fats from processed foods, with very few fruits and vegetables. Patients with kidney disease need to be cautious because this diet could worsen their condition. Additionally, some patients may feel a little tired in the beginning, while some may have bad breath, nausea, vomiting, constipation, and sleep problems.

At the first visit, participants were instructed how to follow the LCKD as individuals or in small groups, with an initial goal of ≤20 g carbohydrate per day. Participants were taught the specific types and amounts of foods they could eat, as well as foods to avoid. Initially, participants were allowed unlimited amounts of meats, poultry, fish, shellfish, and eggs; 2 cups of salad vegetables per day; 1 cup of low-carbohydrate vegetables per day; 4 ounces of hard cheese; and limited amounts of cream, avocado, olives, and lemon juice. Fats and oils were not restricted except that intake of trans fats was to be minimized. Participants were provided a 3-page handout and a handbook [11] detailing these recommendations. Participants prepared or bought all of their own meals and snacks following these guidelines.


Dr. Jockers, thank you so much for this clear and detailed article! I began a keto-style diet around August 2019. By late November, I had fallen from 197 lbs. to under 175 lbs., dropped from 28% to 18% body fat, and anecdotally felt much better in all aspects of my health. All of this occurred exclusively due to diet, I believe– I had almost no exercise routine to speak of, and my desk-based job is pretty sedentary. My family practice doc was surprised and happy with the results as well when I met with him in January… until my blood work came back showing total cholesterol at 257, triglycerides at 236, LDL-C at 162, and HDL at 50.
Although the KD has shown promise as an alternative dietary strategy for weight management, it should be approached with caution. Acutely, the KD causes physiological changes which may manifest as the “keto flu,” a set of symptoms which commonly includes headache, nausea, gastrointestinal upset and fatigue. A recent study by Urbain et al. (22) illustrates this point, as they state, “Consistent with other studies, our subjects complained about headache, gastrointestinal symptoms, and general weakness mainly during the 1-week metabolic adaptation phase to a KD.” While these symptoms typically resolve within the first one to two weeks, this may present an unpleasant barrier for many individuals to overcome.
24. Watson N.A., Dyer K.A., Buckley J.D., Brinkworth G.D., Coates A.M., Parfitt G., Howe P.R.C., Noakes M., Dye L., Chadwick H., et al. A randomised trial comparing low-fat diets differing in carbohydrate and protein ratio, combined with regular moderate intensity exercise, on glycaemic control, cardiometabolic risk factors, food cravings, cognitive function and psychological wellbeing in adults with type 2 diabetes: Study protocol. Contemp. Clin. Trials. 2015;45:217–225. [PubMed] [Google Scholar]
Melinda – I’m afraid there’s no getting around the fact that one of the Keto requirements is to *calculate your macros,* based on the amount of calories you need to consume each day, in order to (a) maintain your current weight level, or (b) lose weight. Go to an online Keto macro calculator – there’s one linked to a good one on this site, further up the thread. They are generally very easy to use. Then stick to your calculated results, with trust and patience. It may be slow, but you will absolutely see results. I did – and I’ve tried absolutely everything. I barely have time to exercise, but I still lost at least a couple of dress sizes, and I feel absolutely amazing – no more brain fog, tons of energy – maybe too much energy! And best of all, I’m no longer miserable about food, because on Keto, everything is delicious! One final thing in the interest of full disclosure – I am an uber-clean-Keto advocate. I put in the work to eat only healthy fats and carbs from healthy sources. I’m pescatarian – no meats except seafood. I also carefully limit my saturated fat intake to 10% of total calories (the recommended daily allowance), to keep my genetically problematic cholesterol level from skyrocketing, as it did when I first began. This is all working well for me so far – I was able to cut 40 points from my abnormally high LDL (bad cholesterol) level within three months, And hope to get it down to normal levels in three more months. You do want to make sure you get your regular physical exams and monitor your blood work whenever you change your nutritional lifestyle. I wish you the best!
Excess fat mass (FM), especially visceral fat, is associated with a variety of pathological conditions such as hypertension, dyslipidemia, diabetes, and even cancer (1–4), as well as an increase in overall and cardiovascular mortality (2, 5). Very-low-calorie diets are commonly used as obesity treatments; however, a primary concern in using such diets is the amount of fat-free mass (FFM; i.e., muscular tissue) that is lost together with the FM (6). This could produce so-called sarcopenic obesity, that is, the coexistence of an excess of FM and a decline in FFM that yields a near-normal body weight (7). Sarcopenic obesity constitutes a double impact on the health of patients, because the reduction in muscle mass and muscle strength is also a cause of cardiometabolic disorders, such as myocardial infarction and stroke, and other adverse health outcomes (5, 7–9). For these reasons, it is of primary interest to find weight loss strategies that promote preferential loss of FM and preservation of muscle mass and its functional status (i.e., muscle strength) (10–12).
We are brazilian, living in Brazil. My daughter, Isabel, 21y. o., born in 1996, has syndrome of deficiency of Glut1. She was diagnosed around her first year of life. At that time her baby bottle, her begining diet meal, was 50ml water plus 50ml oil plus vitamin. Since then, which means, for 20 years, she is under this diet. For almost 18 years under 4:1 proportion. At this right moment 3:1. The only problem she had since started the diet were kidney stones in 2002. Nothing else. Grateful to the diet she doesn’t take any kind of medicine to avoid seizures. Her health is perfect, no colesterol at all. We are at your will for any issues related to her health.
Boosts energy levels. The sluggishness and lethargy you feel after a heavy carb-filled meal is due to the insulin spike and reactive sharp drop in blood sugars. Eating a high-fat diet provides steady energy and helps you avoid crashes that are associated with eating a high-carb diet. Additionally, since ketones are the brain’s preferred source of energy, a ketogenic diet leaves you feeling more alert and mentally energized without having to supply a steady stream of caloric intake [13].

I am a tradition Conservative voter, I liked UKIP's common sense policies but worried about the antics of some of its people. If Farage can keep the standard of the Brexit Party candidates up, he's onto a winner from both sides of the traditional party voters. The clueless leftie liberals love to label any party to the right as r4cist, UKIP gave them that excuse, but Farage is clearly not r4cist.
Transformation Tuesday::: I wore shorts once last year, i felt good because they were a size 16 I think, down from a size 20. My size 2 shorts in the after picture are now too big. About a year between these pictures and at least 100lbs. I was working out, but @coach_jmo had just had the food conversation with me. It was vacation time and I was sad about not being beach ready in a little over 3 months. 😂 I was still making bad choices to help me cope with my weight gain from Postpartum depression and anxiety. I was still eating horribly, with cheat weekends and lots of pizza. 😂 I still thought exercising was enough to help me reach my goals. Working out 7 days a week with my trainer and a Ketogenic diet have changed my life. Down from a size 18/20 to a Size 0/2, over 130 pounds, and over 115 inches. 🎉🙌🎊
“I am a medical practitioner who has type 1 diabetes. Since adopting a very low-carb lifestyle I have found that day-to-day diabetes management has become so much easier with the added bonus of normal HbA1c. As a result of smaller insulin doses, I am not tied down to strict meal times and can eat when I choose. Similarly, glucose control with exercise is far more predictable. Very low carb for me gives as near to a ‘normal’ life as someone with diabetes can get.”

A CKD offers a way to combat this. It offers a cyclical "refeed" (sometimes also called a carb-up). During this phase, the diet consists mostly of complex carbohydrates, with limited fat, sucrose and fructose. Since the glycogen stores in the liver and muscles are depleted, these carbohydrates go straight to refilling them instead of being added to the body's fat stores. For this reason, the amount of calories consumed during a refeed can be far above an individual's usual dietary intake. While a typical CKD consists of 50g or less of carbohydrate per day, the typical refeed consists of 450-600g of carbohydrate. A weight gain of 1-2 lbs is usually reported during refeeding; this is mainly water and normally lost in 2–4 days.
“As a Diplomate of the American Board of Clinical Lipidology, I help my patients decrease their risk of diabetes, heart disease, stroke, and Alzheimer’s disease. Intermittent fasting, low-carb, high-fat (LCHF) diets, and ketogenic diets have powerful effects on adiposopathy, arterial inflammation, and endothelial dysfunction. Patients often come to me for a consultation because they have developed an extremely high LDL-P while on a ketogenic diet. We work together to improve their lipid profile by optimizing their nutrition and lifestyle using a personalized, integrative approach.”
Keto flu is a real thing. Cutting your carbs to the bone and going into a state of ketosis (where your body burns fat for energy) can bring on a cluster of uncomfortable symptoms, such as headaches, fatigue, muscle aches, nausea, and diarrhea. The side effects are the result of your body transitioning to using fat as its primary source of energy instead of carbs, explains Kristen Mancinelli, MS, RDN, author of The Ketogenic Diet. Once it adapts to the new fuel source (usually within a week or two), you’ll start to feel better.
There is nothing inherently difficult about following a ketogenic diet. We have many patients who do this very easily over many years. The metabolic benefits significantly outway any perceived challenges from limiting particular food types. Uptake would be far more widespread if nutrition professionals left their predujical opinions of SFA’s behind. Finally, given the expertise in Ketogenic Diets at Harvard, Dr David Ludwig, for one springs to mind, I am surprised the author did not avail themselves of the local expertise.
Keto diets are high in healthy fats and protein also tend to be very filling, which can help reduce overeating of empty calories, sweets and junk foods. (4) For most people eating a healthy low-carb diet, it’s easy to consume an appropriate amount of calories, but not too many, since things like sugary drinks, cookies, bread, cereals, ice cream or other desserts and snack bars are off-limits.
There are vegetables that are high in carbs and others low in carbs. The keto diet recommends sticking to the ones low on carbs but encourages you to eat a lot of them. Best vegetables are all green ones to make it easy. And vegetables that grow above the ground (e.g. lettuce) are always better than the ones that grow below the ground (e.g. potatoes)
This is a diet that requires a fair amount of attention to macronutrient quantities in order to work. Unlike the Atkins diet, which only restricts carbs, the ketogenic diet also restricts protein based on your activity level, so that extra protein doesn’t get converted into glucose. When people first go on nutritional ketosis, they sometimes focus on getting their carbs super low (i.e., less than 20 grams per day), and that can cause hormone and mood problems, especially in women. They make up the difference with too much protein, which then converts into sugar. So if you over-restrict carbs and eat too much protein, ketosis may not work. It’s not just a certain amount of carbs you want to target, but the right combination of fat, carbs, and protein for YOU.
Once your body adapts to using fat for fuel (can take anywhere from a couple of weeks to over a month) you'll find your apetite changes and it's very easy to eat very low calorie - you won't feel hungry as often and you'll have an easier time recognizing when you should stop eating. A lot of people on keto naturally fall in to some sort of intermittent fasting (eating only 1, 4, 6 or 8 hours of the day and fasting the rest) because they just aren't hungry.
Although the KD has shown promise as an alternative dietary strategy for weight management, it should be approached with caution. Acutely, the KD causes physiological changes which may manifest as the “keto flu,” a set of symptoms which commonly includes headache, nausea, gastrointestinal upset and fatigue. A recent study by Urbain et al. (22) illustrates this point, as they state, “Consistent with other studies, our subjects complained about headache, gastrointestinal symptoms, and general weakness mainly during the 1-week metabolic adaptation phase to a KD.” While these symptoms typically resolve within the first one to two weeks, this may present an unpleasant barrier for many individuals to overcome.
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