An important strength of this study was the use of 3 different techniques for determining body composition in different settings, i.e., obesity and no ketosis, marked reduction in body weight with high ketosis, and finally, substantial reduction in body weight without ketosis. The tight control of adherence by daily measurement of B-OHB is another relevant strength of this work. A potential limitation of our study could be the sample size; however, because each subject underwent 4 evaluations, enabling each individual subject’s own results to be compared, this adds statistical power to the study and a real difference between the experimental points.
The ketogenic diet is not a benign, holistic, or natural treatment for epilepsy; as with any serious medical therapy, complications may result.[28] These are generally less severe and less frequent than with anticonvulsant medication or surgery.[28] Common but easily treatable short-term side effects include constipation, low-grade acidosis, and hypoglycaemia if an initial fast is undertaken. Raised levels of lipids in the blood affect up to 60% of children[38] and cholesterol levels may increase by around 30%.[28] This can be treated by changes to the fat content of the diet, such as from saturated fats towards polyunsaturated fats, and if persistent, by lowering the ketogenic ratio.[38] Supplements are necessary to counter the dietary deficiency of many micronutrients.[18]
Some previous studies have suggested that very-low-calorie ketogenic (VLCK) diets may be effective tools to manage overweight and obesity (10, 11, 13). VLCK diets are a nutritional intervention that emulate fasting by restricting carbohydrates and fat with a relative increase in protein intake (6). The increased protein content may be partially responsible for the muscle mass preservation (12–14). Importantly, the weight-reducing action of these diets is rapid, and despite the fact that the ketosis state lasts only 60 to 90 days at the start of treatment, the weight reduction remains for up to 2 years (13). Therefore, VLCK diets operate by potent mechanisms to induce weight loss, and various body compartments might be altered. To the best of our knowledge, no studies have exhaustively assessed the changes in body composition associated with this type of diet, and variations in muscle strength have been only assessed in athletes (15).
An extreme form of low-carbohydrate diet – the ketogenic diet – is established as a medical diet for treating epilepsy.[14] Through celebrity endorsement it has become a popular weight-loss fad diet, but there is no evidence of any distinctive benefit for this purpose, and it had a number of side effects.[14] The British Dietetic Association named it one of the "top 5 worst celeb diets to avoid in 2018".[14]
According to one hypothesis, low-carb diets have a distinct “metabolic advantage” over diets with higher carbohydrate content when the amount of calories consumed are the same.3 This metabolic advantage is essentially an increase in the expenditure of energy (calories) on the low-carb diet. Factors that may account for this higher rate of calorie burning include:
This work was supported by the PronoKal Group® and by grants from the Fondo de Investigacion Sanitaria (PE13/00024 and PI14/01012 research projects) and CIBERobn (CB06/003), Instituto de Salud Carlos III–Subdireccion General de Evaluacion y Fomento de la Investigación; Fondo Europeo de Desarrollo Regional, and the Health Department of the Xunta de Galicia, Spain. D.G.A. is grateful to the Colombian Department of Science, Technology and Innovation – COLCIENCIAS as a recipient of their predoctoral scholarship to support his work. The funding sources had no involvement in the study design, recruitment of patients, study interventions, data collection, or interpretation of the results. A PronoKal representative (I.S.) was involved in the study design and revised the final version of the manuscript, without intervention in the analysis of data, statistical evaluation, or final interpretation of the results of this study.
“I have been recommending a low-carbohydrate lifestyle as the foundation of treatment for many medical conditions ever since 1999, when I first became associated with the Atkins’ Center for Complementary Medicine and then became the center’s medical director. I founded my own Center for Balanced health in 2003 to further provide patients with expertise in both traditional and complementary medicine, featuring low-carbohydrate nutrition. The Diet Doctor website is an excellent resource for individuals seeking to adopt a low-carbohydrate lifestyle.”
“Eggs have a lot of vitamins like vitamin A, B complex, D, K, E, calcium, and zinc,” says Ryan Weaver, a personal trainer and keto enthusiast. “That’s why eggs are an excellent choice for breakfast when you follow the keto diet. To avoid getting bored, you can try different ways of preparing the eggs—boiled, fried, or baked. Also, you can combine the eggs with different foods like bacon, ham, cheddar cheese, butter, mayonnaise, so you get a different recipe each day although using the same main ingredient.”
In spite of the scientific evidence and real-life testimonials, not everyone is recommended to go on the ketosis diet. This highly specialized, extremely meticulous diet plan is suited to a particular dieter profile, and may also be harmful to some without the guidance of a doctor. But if performed correctly, the very low-calorie diet may be the only way for you to experience considerable, life-changing weight reduction.

HDL stands for high-density lipoprotein and its primary role in the body is actually to sweep up LDL particles and return them to the liver for recycling. This is because LDL is actually very susceptible to oxidation so it must be cleared from the blood efficiently. This means when LDL is exposed to chronic inflammation, it becomes damaged. The longer LDL remains in the blood stream and the higher your inflammation levels are, the higher your risk of heart disease.
In 1921, Rollin Turner Woodyatt reviewed the research on diet and diabetes. He reported that three water-soluble compounds, β-hydroxybutyrate, acetoacetate, and acetone (known collectively as ketone bodies), were produced by the liver in otherwise healthy people when they were starved or if they consumed a very low-carbohydrate, high-fat diet.[10] Dr. Russell Morse Wilder, at the Mayo Clinic, built on this research and coined the term "ketogenic diet" to describe a diet that produced a high level of ketone bodies in the blood (ketonemia) through an excess of fat and lack of carbohydrate. Wilder hoped to obtain the benefits of fasting in a dietary therapy that could be maintained indefinitely. His trial on a few epilepsy patients in 1921 was the first use of the ketogenic diet as a treatment for epilepsy.[10] 

Purnell JQ, Hokanson JE, Marcovina SM, Steffes MW, Cleary PA, Brunzell JD. Effect of excessive weight gain with intensive therapy of type 1 diabetes on lipid levels and blood pressure: results from the DCCT. Diabetes Control and Complications Trial. JAMA. 1998;280:140–146. doi: 10.1001/jama.280.2.140. [PMC free article] [PubMed] [CrossRef] [Google Scholar]

May cause irregularity. Dramatically increasing your fat intake while drastically cutting your carb intake may cause gastrointestinal issues, ranging from constipation to diarrhea. This is something that should resolve itself when your body gets fat-adapted [5]. There is also the potential for nausea, particularly when switching from a low-fat diet to the ketogenic diet. It can take a while for the gall bladder, pancreas, and liver to adapt to digesting high amounts of fat [17].

Keto flu is a real thing. Cutting your carbs to the bone and going into a state of ketosis (where your body burns fat for energy) can bring on a cluster of uncomfortable symptoms, such as headaches, fatigue, muscle aches, nausea, and diarrhea. The side effects are the result of your body transitioning to using fat as its primary source of energy instead of carbs, explains Kristen Mancinelli, MS, RDN, author of The Ketogenic Diet. Once it adapts to the new fuel source (usually within a week or two), you’ll start to feel better.
Great point – the literature shows that ketogenic macro splits are very protein sparing for weight loss and the body will typically burn fat and glucose and spare lean mass. Dr. Jason Fung makes the analogy that it would be like stacking firewood for the winter and then when winter hits, deciding not to use the firewood and instead use the living room couch!

While you don’t have to be 100% accurate, you can use calorie counting as a starting point. It’s a way to measure how much energy you are actually taking in, and then adjust it to your needs. Obviously, a faster/slower metabolism, activity levels, endocrine problems, etc. will affect the amount of energy you will be expending, and therefore will affect the number of calories you need to take in.
In this section you’ll find the original set of 12 weeks of Keto Menu Plans that thousands and thousands of people have used to lose up to 50 pounds or more on the Keto Diet!  Easy and delicious recipes, shopping lists and prep lists to make your transition into keto foolproof and effective!  You can use an app to input the data if you want to track your macros, but honestly if you’re following these plans closely you shouldn’t need to!
^ Hu T, Mills KT, Yao L, Demanelis K, Eloustaz M, Yancy WS, Kelly TN, He J, Bazzano LA (October 2012). "Effects of low-carbohydrate diets versus low-fat diets on metabolic risk factors: a meta-analysis of randomized controlled clinical trials". American Journal of Epidemiology. 176 Suppl 7 (Suppl 7): S44–54. doi:10.1093/aje/kws264. PMC 3530364. PMID 23035144.
During the 1920s and 1930s, when the only anticonvulsant drugs were the sedative bromides (discovered 1857) and phenobarbital (1912), the ketogenic diet was widely used and studied. This changed in 1938 when H. Houston Merritt, Jr. and Tracy Putnam discovered phenytoin (Dilantin), and the focus of research shifted to discovering new drugs. With the introduction of sodium valproate in the 1970s, drugs were available to neurologists that were effective across a broad range of epileptic syndromes and seizure types. The use of the ketogenic diet, by this time restricted to difficult cases such as Lennox–Gastaut syndrome, declined further.[10]
What this shows is that there is very little difference in heart disease risk relative to total cholesterol above and below 200. In fact, no significant increase in risk was measured until total cholesterol reached an excess of 240. There also seems to be a protective role that having a total cholesterol above 180 serves both for heart disease and healthy mental function.
In general, you want to eat the minimum amount of protein to preserve lean body mass and not overtax your kidneys. If you eat too much protein, the excess converts to glucose through a process called gluconeogenesis. You don’t want that to occur in ketosis. Instead, eat anti-inflammatory protein—at the minimum amount to preserve or build lean body mass. My favorite sources are wild-caught fish, grass-fed and -finished beef and wild meats (elk, bison, etc.), pasture-raised poultry, nuts, and seeds. Make sure fish has more selenium (which helps protect the brain) than mercury, to mitigate heavy metal toxicity. Good sources that have a safe selenium/mercury ratio include: tuna, opah, wahoo, spearfish, swordfish.
Slowly fulfilling my dream of becoming a walking, talking weight loss ad 🙌🏼😆🐍 . . . . . . . . #weightlossjourney #ketotransformation #lowcarb #loveyourself #beforeandafter #beachbody #keto #ketodiet #jeans #weightloss #hardwork #motivation #throwback #workinprogress #workout #workoutmotivation #fit #fitness #fitgirl #fitnessmotivation #fitspo #nocaptionneeded #nocarbs @ruthmayketo
Previous studies have shown that ketogenic diets preferably reduce the total FM in obese patients (10–13). However, the precise distribution of these losses has not been determined. In this study we confirmed that the diet reduces total FM and specifically visceral adipose tissue, which has a greater impact in predicting cardiometabolic complications associated with obesity than does the total volume of body adiposity (2, 31).
It has been repeatedly found that in the long-term, all diets with the same calorific value perform the same for weight loss, except for the one differentiating factor of how well people can faithfully follow the dietary programme.[27] A study comparing groups taking low-fat, low-carbohydrate and Mediterranean diets found at six months the low-carbohydrate diet still had most people adhering to it, but thereafter the situation reversed: at two years the low-carbohydrate group had the highest incidence of lapses and dropouts.[27] This may be due to the comparatively limited food choice of low-carbohydrate diets.[27]
One theory is that an extreme increase in cholesterol may be common in those undergoing rapid weight loss. This is because the fat cells we have stored in our adipose tissue contain high amounts of both triglycerides and cholesterol. When we begin to break down our stored fat to be metabolized for energy, cholesterol in the blood goes up temporarily.

The likely reason they were able to keep the weight off, researchers say, is their resting metabolic rate (RMR) was maintained, and they retained their lean muscle mass. RMR is a measure of metabolism (meaning how your body uses energy), while immobile, and it plays an important role in sustaining weight loss, according to other research, published in August 2016 in the journal Obesity.
Never before had the judging panel unanimously decided to each invest millions of dollars into a potential company. But was a different story. A Low Cost - No Exercise Way to lose weight? The sharks got on board - and did it quickly. Kevin Daryl, a nutrionist, created the product to help the millions of people who have trouble losing weight. "Most people want to lose weight, but don't know how - they have other issues preventing them from losing weight the traditional way. With our product, they don't need to change anything, they can just add the supplement to their diet and start seeing the weight loss. - It's Keto, the easy way!" He launched the product for sale through his company website and it sold out within 5 minutes. “We even made sure we had more product than we thought we could sell, but all of it sold out within five minutes!” exclaimed Daryl said.
Conceptualization, A.I.C., A.B.C., P.L.-J., F.F.-A. and F.F.C.; Data curation, A.I.C. and D.G.-A.; Formal analysis, R.G., Z.A. and S.J.-M.; Investigation, A.I.C., D.G.-A., A.B.C. and F.F.C.; Methodology, A.B.C., I.S., F.F.-A. and F.F.C.; Supervision, F.F.C.; Writing—original draft, A.I.C., D.G.-A., A.B.C. and F.F.C.; Writing—review & editing, A.I.C., D.G.-A., A.B.C., R.G., Z.A., S.J.-M., I.S., P.L.-J., F.F.-A. and F.F.C.
Dinner: In a small sauce pan bring 2-3 cups of water to the boil. Cook a large egg in rolling boil for 5 minutes, then transfer to ice bath (a bowl with cold water and ice cubes in it). Wash and spin dry butter lettuce, top with sliced avocado and hemp seed. Serve soft boiled egg with cherry tomatoes, butter lettuce salad and mayonnaise as dressing.
But what about body fat? Hall and Guo investigated 20 controlled feeding studies that reported changes in body fatness on equal-calorie diets differing in fat and carbohydrate content. They found that each diet has similar effects on body fatness, which makes sense when you consider the finding that neither diet provides a significant metabolic advantage.   (Yet higher-carbohydrate diets seem to cause a slightly more substantial loss of body fat per calorie — a 16 gram per day difference.)
There is evidence that the quality, rather than the quantity, of carbohydrate in a diet is important for health, and that high-fiber slow-digesting carbohydrate-rich foods are healthful while highly-refined and sugary foods are less so.[4] People choosing diet for health conditions should have their diet tailored to their individual requirements.[19] For people with metabolic conditions, in general a diet with approximately 40-50% high-quality carbohydrate is compatible with what is scientifically established to be a healthy diet.[19]
Changes in food craving during the very low-calorie-ketogenic diet treatment. (A) Food craving trait and state. (B) Food craving inventory. Data represent mean ± standard error of changes from baseline. (ƚ) Denotes statistically significant differences through the intervention (p for trend < 0.05) evaluated by means of repeated-measures ANOVA. (*) Denotes statistically significant differences (p < 0.05) from baseline after post-hoc pairwise comparisons employing the Tukey’s adjustment for multiple comparisons.
A final guideline: Even if you’re keto, portions of fat still matter, says Jill Keene, RDN, in White Plains, New York. “How much you specifically eat depends on your calorie needs and goals, but overconsuming fat can cause weight gain,” she says. Also, considering fat is your body’s main fuel source on a keto diet, she advises spreading out your fats evenly throughout the day.

I’ve been on WFPB diet for 8 months because of high chloresterol and it didn’t drop any, but my husband did the diet with me and his went way down. I have decided to try low carb diet for the next 3 months and do labs to see if it helps. Then I might try keto after that, but between doing WFPB and low carb, I like WFPB best! My doctor said my chloresterol might be “genes”! Loved reading about different diets! I may just need pills or have high chloresterol! Nancy
If you’re looking to get a jump start on your health and fitness goals this year, you may be thinking about trying the ketogenic diet. Maybe you’ve heard the phrase before — it’s a huge diet buzzword — but aren’t sure what it means. Here’s a primer: The ketogenic diet is an eating plan that drives your body into ketosis, a state where the body uses fat as a primary fuel source (instead of carbohydrates), says Stacey Mattinson, RDN, who is based in Austin, Texas.
1. West, R., Beeri, M. S., Schmeidler, J., Hannigan, C. M., Angelo, G., Grossman, H. T., … Silverman, J. M. (2008). Better memory functioning associated with higher total and low-density lipoprotein cholesterol levels in very elderly subjects without the apolipoprotein e4 allele. The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry, 16(9), 781–5. PMID: 18757771

This process of burning fat provides more benefits than simply helping us to shed extra weight — it also helps control the release of hormones like insulin, which plays a role in development of diabetes and other health problems. When we eat carbohydrates, insulin is released as a reaction to elevated blood glucose (an increase in sugar circulating in our blood) and insulin levels rise. Insulin is a “storage hormone” that signals cells to store as much available energy as possible, initially as glycogen (aka stored carbohydrates in our muscles) and then as body fat.
“I have been applying low carb solutions to metabolic problems since the moment I closed the cover of Good Calories, Bad Calories. I share with my low-carb colleagues the wonderful experience of offering effective advice and seeing real results. In addition to metabolic and hormonal problems, I have more recently focused on flexible low-carb approaches for Alzheimer’s and other neurodegenerative conditions. I greatly enjoy the lively online low-carb community and rely on Diet Doctor as a resource for myself and my patients.”

When we constantly consume sugar, we release dopamine in our brain – creating an addiction and an increased tolerance. Over time you will have to eat larger and larger amounts of sugar to continue the dopamine secretion. Once our body is dependent on a chemical reaction in the brain, we can find that we’re craving things even when we’re not hungry.


Ketosis improves certain forms of cellular healing, including mitochondrial biogenesis (the making of new, bigger, and higher energy-producing mitochondria), so that your cells are stronger and have more stamina, particularly when it comes to exercise. For example, some endurance and ultra-endurance athletes believe that their performance improves in nutritional ketosis compared to sugar burning, when they have more fat than carb reserves. But because of the limited data, and available data suggesting that athletes may actually perform worse on nutritional ketosis, I do not currently recommend it for elite athletes.
In the mid-1990s, Hollywood producer Jim Abrahams, whose son's severe epilepsy was effectively controlled by the diet, created the Charlie Foundation to promote it. Publicity included an appearance on NBC's Dateline programme and ...First Do No Harm (1997), a made-for-television film starring Meryl Streep. The foundation sponsored a multicentre research study, the results of which—announced in 1996—marked the beginning of renewed scientific interest in the diet.[1]
Muscular strength was measured with a Jamar handgrip dynamometer (Lafayette Instruments, Lafayette, IN). After a brief demonstration and verbal instructions, the test was performed in the standing position with the wrist in the neutral position and the elbow flexed to 90 degrees. Patients were given verbal encouragement to squeeze as hard as possible and to apply maximal effort for at least 3 seconds. Two trials were allowed in the dominant limb, and the highest score was recorded as peak grip strength (kg). Considering possible influences on the muscular strength of changes in body composition, handgrip strength (HG) was divided by appendicular lean mass (ALM) determined by DXA (HG/ALM) and by appendicular soft lean mass (ASLM) determined by MF-BIA (HG/ASLM).
But what does the science say? Results are mixed. In one Spanish study of 20 obese adults, participants were put on a low-calorie keto diet and lost an average of 40 pounds over four months. Another small experiment had a similar outcome. In a six-month Experimental & Clinical Cardiology study of 83 obese adults, those on the keto diet lost an average of 33 pounds, while lowering their bad (LDL) cholesterol levels and increasing their good (HDL) cholesterol.
The following measurements were made every other week: anthropometric and vital sign measurements; urine testing for ketones; and assessment for hypoglycemic episodes and other symptomatic side effects. Weight was measured on a standardized digital scale while the participant was wearing light clothes and shoes were removed. Skinfold thickness was measured at 4 sites – the average of 2 measurements at each site was entered into an equation to calculate percent body fat [12]. Waist circumference was measured at the midpoint between the inferior rib and the iliac crest using an inelastic tape; 2 measurements were averaged in the analysis. Blood pressure and heart rate were measured after the participant had been seated quietly without talking for 3 minutes. Certified laboratory technicians assessed urine ketones from a fresh specimen using the following semi-quantitative scale: none, trace (up to 0.9 mmol/L [5 mg/dL]), small (0.9–6.9 mmol/L [5–40 mg/dL]), moderate (6.9–13.8 mmol/L [40–80 mg/dL]), large80 (13.8–27.5 mmol/L [80–160 mg/dL]), large160 (>27.5 mmol/L [160 mg/dL]). Hypoglycemic episodes and symptomatic side effects were assessed by direct questioning of the participant and by self-administered questionnaires.
This content is strictly the opinion of Dr. Josh Axe and is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. All readers/viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. Neither Dr. Axe nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. All viewers of this content, especially those taking prescription or over-the-counter medications, should consult their physicians before beginning any nutrition, supplement or lifestyle program.

The weight-loss program has five steps and adheres to the most recent guidelines of the 2015 EFSA on total carbohydrate intake [22]. The first three steps consist of a VLCK diet (600–800 kcal/day), low in carbohydrates (<50 g daily from vegetables), and lipids (only 10 g of olive oil per day). The amount of high biological-value proteins ranged between 0.8 and 1.2 g per each kg of ideal body weight to ensure that patients were meeting their minimum body requirements and to prevent the loss of lean mass. In step 1, the patients ate high-biological-value protein preparations five times a day and vegetables with low glycemic indexes. In step 2, one of the protein servings was substituted with a natural protein (e.g., meat or fish) either at lunch or at dinner. In step 3, a second serving of low-fat natural protein was substituted for the second serving of biological protein preparation. Throughout these ketogenic phases, supplements of vitamins and minerals, such as K, Na, Mg, Ca, and omega-3 fatty acids, were provided in accordance with international recommendations [23]. These three steps were maintained until the patient lost the target amount of weight, ideally 80%. Hence, the ketogenic steps were variable in time depending on the individual and the weight-loss target. The total ketosis state lasted for 60–90 days only.
Keto diets are high in healthy fats and protein also tend to be very filling, which can help reduce overeating of empty calories, sweets and junk foods. (4) For most people eating a healthy low-carb diet, it’s easy to consume an appropriate amount of calories, but not too many, since things like sugary drinks, cookies, bread, cereals, ice cream or other desserts and snack bars are off-limits.
What is the keto diet? Rather than relying on counting calories, limiting portion sizes, resorting to extreme exercise or requiring lots of willpower, this low-carb diet takes an entirely different approach to weight loss and health improvements. It works because it changes the very “fuel source” that the body uses to stay energized: namely, from burning glucose (or sugar) to dietary fat, courtesy of keto diet recipes and the keto diet food list items, including high-fat, low-carb foods.

“As an ophthalmologist, I use a low-carb, high-fat diet approach with intermittent fasting to treat and prevent vision loss associated with diabetic retinopathy in my patients. In addition to my ophthalmology practice, I also treat patients with obesity and metabolic diseases with positive results. I recommend the Diet Doctor website to all my patients so that they get a deep understanding of the low-carb, high-fat approach. It has all the valuable resources they need for a successful ketogenic lifestyle.”
This was a great read. I aim to restrict carbs always because I believe most are why the American population is obese. I would very much like to hear more about carb restriction excluding the discussion on processed meats and processed high salt content foods because I consume neither. I also don’t consume dairy or eggs. So can you provide some substance.
Boosts energy levels. The sluggishness and lethargy you feel after a heavy carb-filled meal is due to the insulin spike and reactive sharp drop in blood sugars. Eating a high-fat diet provides steady energy and helps you avoid crashes that are associated with eating a high-carb diet. Additionally, since ketones are the brain’s preferred source of energy, a ketogenic diet leaves you feeling more alert and mentally energized without having to supply a steady stream of caloric intake [13].
This week we’re getting stricter with our fasting. We had a full week of intermittent fasting and now we’re going to skip breakfast and lunch. Water is our BEST friend here! Don’t forget that you can drink coffee, tea, flavored water, and the like to get your liquids in. Keep drinking to make sure you’re not thinking about your stomach. It MIGHT start growling, just ignore it – your body will adjust with time.
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