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To drill down further, there are some genetic enzyme defects that cause problems with ketosis. Here are a few of note: carnitine deficiency (primary), carnitine palmitoyltransferase (CPT) I or II deficiency, carnitine translocase deficiency, beta-oxidation defects—mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase (mHMGS) deficiency, medium-chain acyl dehydrogenase deficiency (MCAD).


The severe reduction in body weight was mainly a result of FM reduction, as assessed by DXA scan; the −20.2 kg of weight reduction at the end of the study was in large part due to the −16.5 kg reduction in FM. When the FM compartment was assessed by MF-BIA, the result was very similar (−18.2 kg) and was further corroborated by the ADP analysis [−17.7 kg; Fig. 2(A)], without statistical differences among the results. It was remarkable that 3 methods of evaluating body composition, which operate through different principles, yielded such similar results. FM loss represents nearly 85% of the total weight loss achieved across the study.


My Husband and I started doing Keto July 2018. We got over weight after we got out of the Marine Corps. It has been hard to workout because I became disabled, but my diet was not good. After our friend Amber recommended your site and support group, we found a lot of helpful information to get us started on a successful journey. So far it’s been one month and we have lost 18 pounds each!
I ate a lot of bacon, cheese, eggs and meat (steak and chicken mostly). For a person whose eating philosophy is typically more plant-based and whole-food-focused, eating processed pork products every morning took a lot of personal persuasion. It also took a complete mental shift, because eating multiple pieces of bacon every day for weeks on end goes against everything I've been taught for personal health.
On a ketogenic diet, you’re generally eating a diet that’s high in fat (roughly 70 percent of your total calories come from fat), moderate in protein (about 20 percent of your calories), and low in carbohydrate (about 5 percent of calories). By limiting carbohydrates (to usually less than 45 grams for the average person), your body lacks the glucose (from carbs) that it normally uses for energy, so it eventually switches over to burning fat as its primary fuel source instead; through a metabolic process called ketosis, the liver converts the fat into fragments of fatty acids called ketones, which power the brain and other organs and tissues.
27. O’Connor D.B., Corona G., Forti G., Tajar A., Lee D.M., Finn J.D., Bartfai G., Boonen S., Casanueva F.F., Giwercman A., et al. Assessment of sexual health in aging men in Europe: Development and validation of the european male ageing study sexual function questionnaire. J. Sex. Med. 2008;5:1374–1385. doi: 10.1111/j.1743-6109.2008.00781.x. [PubMed] [CrossRef] [Google Scholar]

The ketogenic diet is a mainstream dietary therapy that was developed to reproduce the success and remove the limitations of the non-mainstream use of fasting to treat epilepsy.[Note 2] Although popular in the 1920s and '30s, it was largely abandoned in favour of new anticonvulsant drugs.[1] Most individuals with epilepsy can successfully control their seizures with medication. However, 20–30% fail to achieve such control despite trying a number of different drugs.[9] For this group, and for children in particular, the diet has once again found a role in epilepsy management.[1][10]


I won't be staying with keto for the long term—I really can't eat that much bacon anymore—but I do expect I'll return to it several times a year. If nothing else, the strict diet works well for me as a reset after a long splurge (hello, holidays!), and my month-long experiment helped me break my dependency on some of my biggest food crutches (sugar, pasta, crackers).
While you don’t have to be 100% accurate, you can use calorie counting as a starting point. It’s a way to measure how much energy you are actually taking in, and then adjust it to your needs. Obviously, a faster/slower metabolism, activity levels, endocrine problems, etc. will affect the amount of energy you will be expending, and therefore will affect the number of calories you need to take in.
Yes, you'll lose weight but only because you're consuming fewer calories. There's no real magic to the keto diet. The weight-loss equation remains the same: You lose weight when you consume fewer calories than you use each day. You're not burning more fat than other diets, or at a faster rate. On the keto diet, you eat high-fat meals with protein, which keeps you feeling full for longer and cuts down on your overall eating throughout the day.

“I have been applying low carb solutions to metabolic problems since the moment I closed the cover of Good Calories, Bad Calories. I share with my low-carb colleagues the wonderful experience of offering effective advice and seeing real results. In addition to metabolic and hormonal problems, I have more recently focused on flexible low-carb approaches for Alzheimer’s and other neurodegenerative conditions. I greatly enjoy the lively online low-carb community and rely on Diet Doctor as a resource for myself and my patients.”
Achieving ketosis is a pretty straightforward, but it can seem complicated and confusing with all of the information out there.4If you want to learn more about ketosis and the scientific process around it, you can visit a very in-depth discussion about on Dr. Peter Attia’s website. Here’s the bottom line on what you need to do, ordered in levels of importance:
d) Or does the entire question revert back to a classic calorie counting exercise? In this case, I’ll eat the minimum amount of protein that is needed to prevent my muscles from being cannibalized (for energy) and for the rest, I’ll limit my dietary fat intake per day to a level, where its energy + energy currently obtained from adipose tissue match my total energy need? (I’ll leave gluconeogenesis out of this equation for simplicity.) If this is the case, I’ll lose adipose tissue, i.e. lose weight, but the interesting question still remains: How much energy can my body extract from the adipose tissue at its best? How can I maximize the share of energy coming from adipose tissue instead of dietary fat?
Specific fiber goals for every day will depend on your overall intake, current weight, and weight-loss intentions. Thankfully, some high-fat, low-carb foods are also loaded with fiber. These include nuts and seeds, avocado, and squash. “I see so many clients go for high protein, high saturated fat, and no carb,” says Sunny Brigham, MS, CNS, a board-certified nutrition specialist with a private clinic in North Texas. “They become constipated because they aren’t getting enough fiber.” And that’s just one of the 11 hidden dangers of the keto diet.

Slowly fulfilling my dream of becoming a walking, talking weight loss ad 🙌🏼😆🐍 . . . . . . . . #weightlossjourney #ketotransformation #lowcarb #loveyourself #beforeandafter #beachbody #keto #ketodiet #jeans #weightloss #hardwork #motivation #throwback #workinprogress #workout #workoutmotivation #fit #fitness #fitgirl #fitnessmotivation #fitspo #nocaptionneeded #nocarbs @ruthmayketo
Being constantly stressed keeps your sugar-boosting hormone cortisol jacked up, which not only elevates your blood sugar but also short-circuits fat loss. And let's be honest: When you're stressed out, you're more likely to nose-dive into keto-unfriendly foods, like comfort carbs. Find ways to dial down stress levels. I find even five minutes of shutting my eyes and taking deep, diaphragmatic breaths can give me a renewed focus and take stress down a few notches.
Because visceral fat is physiologically and clinically more relevant than total FM, special emphasis was placed on its analysis. The VLCK diet led to a significant reduction in visceral fat that can be seen in assessment by either new DXA software (−1.2 ± 0.7 kg) or by MF-BIA [−60.8 ± 20.7 cm2; Fig. 2(B) and 2(C)]. Therefore, when evaluated by different methods, the VLCK diet induced a significant body weight reduction by targeting total FM and visceral FM [Fig. 2(A–C)].
The modified Atkins diet reduces seizure frequency by more than 50% in 43% of patients who try it and by more than 90% in 27% of patients.[18] Few adverse effects have been reported, though cholesterol is increased and the diet has not been studied long term.[48] Although based on a smaller data set (126 adults and children from 11 studies over five centres), these results from 2009 compare favourably with the traditional ketogenic diet.[18]

Very low calorie diets are not something you should try alone. Consuming over-the-counter meal replacement products is not the same kind of treatment your doctor will provide you. In addition, ketones are not the ideal energy supplier — but rather a "will do" supplier — and this underscores how important it is that VLCDs are short in duration and guided by a qualified health care professional. In addition, many VLCD treatments involve supplementing with prescription medications to help with weight loss, which provides a measure of effectiveness you are not likely to get by going it alone.


Very low calorie diets are not something you should try alone. Consuming over-the-counter meal replacement products is not the same kind of treatment your doctor will provide you. In addition, ketones are not the ideal energy supplier — but rather a "will do" supplier — and this underscores how important it is that VLCDs are short in duration and guided by a qualified health care professional. In addition, many VLCD treatments involve supplementing with prescription medications to help with weight loss, which provides a measure of effectiveness you are not likely to get by going it alone.
Psyllium husk powder is what you’ll need, and you can find it on Amazon. Flaxseed Meal is another ingredient you can use to provide a slightly chewy texture. Although I feel that it’s not as good as psyllium (as it gives a slightly gelled texture), many people have used it successfully in place of psyllium. Make sure you grab a pack or 3 from Amazon. It’s super cheap and lasts a long time!
While keto diets minimize sugar and other food sensitivities, they often allow full-fat dairy such as yogurt that, for some people, can stall fat loss. And some packaged keto-friendly foods (yes, there's a whole industry of keto-friendly cookies, candy, and other junk food!) can contain gluten, artificial sweeteners, and other reactive ingredients. These foods and additives cause dysbiosis (an imbalance between good and bad bugs), leaky gut syndrome, and increase insulin resistance, which raises blood sugar levels—stalling weight loss. Read your labels carefully: Food sensitivities can be sneaky and hide in foods that you would never suspect, like mustard.
Ketogenic diets focus on high amounts of fat in the diet, including saturated fats, along with very restricted amounts of carbohydrates, in order to create ketones that bypass insulin resistance in brain cells and energize their metabolic functions in lieu of glucose. This has proven efficacious for other central nervous systems problems in addition to Alzheimer’s and epilepsy.

Weight loss is the primary reason my patients use the ketogenic diet. Previous research shows good evidence of a faster weight loss when patients go on a ketogenic or very low carbohydrate diet compared to participants on a more traditional low-fat diet, or even a Mediterranean diet. However, that difference in weight loss seems to disappear over time.
I’ve been trying this keto diet that my dr.and daughter recommended, it’s been close to a week. I’ve changed my food intake, no bad carbs that I know of, was a huge chip addict stopped all that with no cravings. I’m not seeing any results I’m getting discouraged and everything sounds so complicated watching this, measuring that, I don’t have a clue what I’m doing. just that I stopped bread,pasta,poratoes,rice all those kind of carbs.I’m drinking more water eating green vegetables and trying to increase my fat intake. I don’t feel motivated to exercise which probably doesn’t help and have 100-130 to lose. I need help I don’t understand or have the time create a lot of meals and measure my fat,protein and carb intake.
^ Ketogenic "eggnog" is used during induction and is a drink with the required ketogenic ratio. For example, a 4:1 ratio eggnog would contain 60 g of 36% heavy whipping cream, 25 g pasteurised raw egg, saccharin and vanilla flavour. This contains 245 kcal (1,025 kJ), 4 g protein, 2 g carbohydrate and 24 g fat (24:6 = 4:1).[17] The eggnog may also be cooked to make a custard, or frozen to make ice cream.[37]

Many unhealthy foods easily meet keto’s low-carb, high-fat criteria. However, that doesn’t mean you can or should eat them freely. “A huge benefit to following the keto diet is that the vast majority of processed food is removed with the removal of grains,” Santo says. “Unfortunately, poor-quality dairy, meat, and veggies may fill the gap.” Look for healthier sources of protein and fat, such as grass-fed meats, and limit processed dairy (think cheese singles) as much as possible.
Thanks for all the info. Just found Endame Pasta at Hannafords. Two ounces (a hefty plateful) is just 9 net carbs. It’s absolutely delicious with a sauce made of mushrooms & shrimp sauteed in olive oil, a bit of butter and garlic and shredded cheese to top it off (hand shredded of course). I’d only had 6 grams of carbs today and decided to give it a try. Yum. So glad I did. Easy & quick supper.
I’m 50 and have been working out with weights and cardio for over 30 years, 6-7 days per week. I have always had controlled weight in the 180’s for 5′ 9″ due to strength training. I went on a “version” of the Keto diet—per day goals: 35 net carbs/85-95 grams protein/35-40 grams fat. I didn’t want to go all-in with high fats. I weighed 188 at the start and in 6 months dropped 26 lbs to 162, and bodyfat at 9%. My cholesterol levels have mostly been 220 with 50-75 HDL.
Bulk buy and cook. If you’re someone who doesn’t like to spend a lot of time in the kitchen, this is the best of both worlds. Buying your food at bulk (specifically from wholesalers) can reduce the cost per pound tremendously. Plus, you can make ahead food (bulk cook chicken thighs for pre-made meat, or cook entire meals) that are used as leftovers, so you spend less time cooking.
An extreme form of low-carbohydrate diet – the ketogenic diet – is established as a medical diet for treating epilepsy.[14] Through celebrity endorsement it has become a popular weight-loss fad diet, but there is no evidence of any distinctive benefit for this purpose, and it had a number of side effects.[14] The British Dietetic Association named it one of the "top 5 worst celeb diets to avoid in 2018".[14]

There is a lot of information out there on the ketogenic diet, and sometimes that abundance of information can be confusing!  Do you need to count macros? What are macros anyway?!?  How many carbs can I eat on the Keto Diet?  What is keto flu?  How do you get enough electrolytes in your Keto Diet to avoid cramps and other keto flu symptoms?  How much water should you drink?  Is diet soda ok on keto?  What foods are keto approved?  Will I gain the weight back after keto?  Is the Keto Diet safe?


“Your liver produces ketones all the time, but the rate depends on carbohydrate and protein intake,” says Jeff Volek, Ph.D., R.D., a professor of human sciences at Ohio State University. When the majority of your diet is made up of of carbs and protein, ketogenesis slows. Replacing carbs and protein with fat will put your body into ketosis, thus ramping up ketone production. This takes about three days to induce.
A ketogenic diet could be an interesting alternative to treat certain conditions, and may accelerate weight loss. But it is hard to follow and it can be heavy on red meat and other fatty, processed, and salty foods that are notoriously unhealthy. We also do not know much about its long-term effects, probably because it’s so hard to stick with that people can’t eat this way for a long time. It is also important to remember that “yo-yo diets” that lead to rapid weight loss fluctuation are associated with increased mortality. Instead of engaging in the next popular diet that would last only a few weeks to months (for most people that includes a ketogenic diet), try to embrace change that is sustainable over the long term. A balanced, unprocessed diet, rich in very colorful fruits and vegetables, lean meats, fish, whole grains, nuts, seeds, olive oil, and lots of water seems to have the best evidence for a long, healthier, vibrant life.
Dr. Jockers, thank you so much for this clear and detailed article! I began a keto-style diet around August 2019. By late November, I had fallen from 197 lbs. to under 175 lbs., dropped from 28% to 18% body fat, and anecdotally felt much better in all aspects of my health. All of this occurred exclusively due to diet, I believe– I had almost no exercise routine to speak of, and my desk-based job is pretty sedentary. My family practice doc was surprised and happy with the results as well when I met with him in January… until my blood work came back showing total cholesterol at 257, triglycerides at 236, LDL-C at 162, and HDL at 50.
When we constantly consume sugar, we release dopamine in our brain – creating an addiction and an increased tolerance. Over time you will have to eat larger and larger amounts of sugar to continue the dopamine secretion. Once our body is dependent on a chemical reaction in the brain, we can find that we’re craving things even when we’re not hungry.
Yes, you'll lose weight but only because you're consuming fewer calories. There's no real magic to the keto diet. The weight-loss equation remains the same: You lose weight when you consume fewer calories than you use each day. You're not burning more fat than other diets, or at a faster rate. On the keto diet, you eat high-fat meals with protein, which keeps you feeling full for longer and cuts down on your overall eating throughout the day.
After initiation, the child regularly visits the hospital outpatient clinic where they are seen by the dietitian and neurologist, and various tests and examinations are performed. These are held every three months for the first year and then every six months thereafter. Infants under one year old are seen more frequently, with the initial visit held after just two to four weeks.[9] A period of minor adjustments is necessary to ensure consistent ketosis is maintained and to better adapt the meal plans to the patient. This fine-tuning is typically done over the telephone with the hospital dietitian[19] and includes changing the number of calories, altering the ketogenic ratio, or adding some MCT or coconut oils to a classic diet.[18] Urinary ketone levels are checked daily to detect whether ketosis has been achieved and to confirm that the patient is following the diet, though the level of ketones does not correlate with an anticonvulsant effect.[19] This is performed using ketone test strips containing nitroprusside, which change colour from buff-pink to maroon in the presence of acetoacetate (one of the three ketone bodies).[45]
A low-carbohydrate diet gives slightly better control of glucose metabolism than a low-fat diet in type 2 diabetes.[12][34] A 2018 report on type 2 diabetes by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) found that a low-carbohydrate diet may not be as good as a Mediterranean diet at improving glycemic control, and that although having a healthy body weight is important, "there is no single ratio of carbohydrate, proteins, and fat intake that is optimal for every person with type 2 diabetes".[35]
I wanted to put it out there that I made this meal plan specifically with women in mind. I took an average of about 150 women and what their macros were. The end result was 1600 calories – broken down into 136g of fat, 74g of protein, and 20g net carbs a day. This is all built around a sedentary lifestyle, like most of us live. If you need to increase or decrease calories, you will need to do that on your own terms.
Ariel Warren is a Registered Dietitian, Diabetes Educator, graduate from Brigham Young, and was diagnosed with Type 1 at the age of 4 years old. Ariel understands diabetes and enjoys working with clients to improve their blood sugar management, healthy eating, weight loss, fitness, and pregnancy. For coaching from a T1D Dietitian, you can contact Ariel directly, through her website: arielwarren.com.
The following measurements were made every other week: anthropometric and vital sign measurements; urine testing for ketones; and assessment for hypoglycemic episodes and other symptomatic side effects. Weight was measured on a standardized digital scale while the participant was wearing light clothes and shoes were removed. Skinfold thickness was measured at 4 sites – the average of 2 measurements at each site was entered into an equation to calculate percent body fat [12]. Waist circumference was measured at the midpoint between the inferior rib and the iliac crest using an inelastic tape; 2 measurements were averaged in the analysis. Blood pressure and heart rate were measured after the participant had been seated quietly without talking for 3 minutes. Certified laboratory technicians assessed urine ketones from a fresh specimen using the following semi-quantitative scale: none, trace (up to 0.9 mmol/L [5 mg/dL]), small (0.9–6.9 mmol/L [5–40 mg/dL]), moderate (6.9–13.8 mmol/L [40–80 mg/dL]), large80 (13.8–27.5 mmol/L [80–160 mg/dL]), large160 (>27.5 mmol/L [160 mg/dL]). Hypoglycemic episodes and symptomatic side effects were assessed by direct questioning of the participant and by self-administered questionnaires.

Positive science on ketosis coupled with personal successes passed by word-of-mouth have driven more people to explore the ketogenic diet, says Volek. More recently, the keto diet hints at having a promising therapeutic role in cancer, Alzheimer’s, Parkinson’s and polycystic ovary syndrome (PCOS). Research is still early in many areas, but Volek suspects there will more definitive answers on the wider scope of the diet’s benefits within the next decade.

Dietary fiber keeps you full longer and contains prebiotic nutrients that support a healthy gut flora, creating a win-win for weight loss. Getting insufficient dietary fiber (yes, I'm talking to you, all-meat carnivore or cave-man diet folks) adversely shifts your healthy gut flora, which will increase inflammation, insulin resistance, fat deposition around the middle, and weight gain. Leafy green and cruciferous vegetables, avocado, coconut, and berries make great fiber-rich, keto-friendly foods.
When the craving for alcohol was evaluated, no statistically significant changes were observed in the MACS scores through the nutritional intervention, taking all patients together (Table S1). However, when the analysis was performed considering the gender of participants in the study, men experienced a significant decrease in the total score through the study (p = 0.047). This decrease was more notable in the maximum ketosis phase as compared with baseline (−15.14; p = 0.047). Moreover, a statistically significant reduction was observed in the lack of inhibition item (−27.19; p = 0.042).
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