“The totality of evidence is very clear: A low-carbohydrate dietary approach is the most effective way to manage the insulin resistance syndrome which is that single biggest driver of obesity, type 2 diabetes and cardiovascular disease. Diet Doctor has been instrumental in providing extremely useful, clear and educational material to all who want to implement this dietary approach in to their lives. That’s why I recommend the website to all my at-risk patients.”
“I have been applying low carb solutions to metabolic problems since the moment I closed the cover of Good Calories, Bad Calories. I share with my low-carb colleagues the wonderful experience of offering effective advice and seeing real results. In addition to metabolic and hormonal problems, I have more recently focused on flexible low-carb approaches for Alzheimer’s and other neurodegenerative conditions. I greatly enjoy the lively online low-carb community and rely on Diet Doctor as a resource for myself and my patients.”

Your individual fat adaptation period. Remember your body needs time to become fat-adapted and that time depends on your metabolism. For instance, if you’re coming off a Standard American Diet (SAD) and your adult body has never run on ketones before, your adaptation period might take a little longer. You’ll only experience the true weight loss effects of keto when your body is actually running on ketones.


A cyclic ketogenic diet (or carb-cycling) is a low-carbohydrate diet with intermittent periods of high or moderate carbohydrate consumption. This is a form of the general ketogenic diet that is used as a way to maximize fat loss while maintaining the ability to perform high-intensity exercise. A ketogenic diet limits the number of grams of carbohydrate the dieter may eat, which may be anywhere between 0 and 50g per day. The remainder of the caloric intake must come primarily from fat sources and protein sources in order to maintain ketosis (the condition in which the body burns fats and uses ketones instead of glucose for fuel).
Remember, the point of the ketogenic diet is to enter ketosis by limiting your carbohydrate intake to about 5% of your total calorie needs and consuming about 75% of your calories in the form of fats. Vegetables and fruits naturally contain carbohydrates, and the ones included in the list above are lower in carbohydrates while not skimping on nutrients.
By design, the nutritional intervention induced an important reduction in BMI and fat mass, especially visceral fat mass through the study visits synchronized with the ketone levels in four visits (Figure 1). Thus, at the end of the nutritional intervention, the patients were out of ketosis (0.2 ± 0.1 mmol/L) with a total of 7.7 units of BMI lost (Figure 1). Most of the initial body composition loss was in the form of total fat mass (Figure 1). Relevantly, from the total fat mass, visceral fat mass, the most physiological and clinically relevant fat depot, was significantly reduced after the VLCK diet (−1.2 ± 0.7 kg; p < 0.05).
In many developing countries, the ketogenic diet is expensive because dairy fats and meat are more expensive than grain, fruit and vegetables. The modified Atkins diet has been proposed as a lower-cost alternative for those countries; the slightly more expensive food bill can be offset by a reduction in pharmaceutical costs if the diet is successful. The modified Atkins diet is less complex to explain and prepare and requires less support from a dietitian.[55]
BHB (Beta-hydroxybutyrate) is the first substrate that kicks the metabolic state of ketosis into action. If you take it, BHB is able to start processing in your body resulting in energy and greatly speed up weight loss by putting your body into ketosis. contains BHB, which forces the body into a constant state of Ketosis, helping you burn fat for energy instead of carbs.
The weight loss program has 5 steps (Supplemental Fig. 1) and adheres to the most recent (2015) European Food Safety Authority guidelines on total carbohydrate intake (17). The first 3 steps consist of a VLCK diet (600 to 800 kcal/d), which is low in carbohydrates [< 50 g (26 to 30 g) per day from vegetables] and lipids (only 10 g of olive oil per day). The amount of high-biological-value proteins range from 0.8 to 1.2 g per kg of ideal body weight to ensure minimal body requirements are met and to prevent the loss of lean mass. In step 1, the patients consumed high-biological-value protein preparations 5 times per day, and vegetables with low glycemic indexes. In step 2, 1 of the protein servings was replaced by a natural protein (e.g., meat or fish) either at lunch or at dinner. In step 3, a second serving of low-fat natural protein replaced the second serving of biological protein. Throughout the ketogenic phases, supplements of vitamins and minerals, such as K, Na, Mg, Ca, and omega-3 fatty acids, were provided in accordance with international recommendations (18). These first 3 steps were maintained until the patient lost the target amount of weight, ideally 80%. Hence, the ketogenic steps were variable in time, depending on the individual and the weight loss target.

To drill down further, there are some genetic enzyme defects that cause problems with ketosis. Here are a few of note: carnitine deficiency (primary), carnitine palmitoyltransferase (CPT) I or II deficiency, carnitine translocase deficiency, beta-oxidation defects—mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase (mHMGS) deficiency, medium-chain acyl dehydrogenase deficiency (MCAD).

Gary D. Foster, Ph.D., Holly R. Wyatt, M.D., James O. Hill, Ph.D., Brian G. McGuckin, Ed.M., Carrie Brill, B.S., B. Selma Mohammed, M.D., Ph.D., Philippe O. Szapary, M.D., Daniel J. Rader, M.D., Joel S. Edman, D.Sc., and Samuel Klein, M.D., “A Randomized Trial of a Low-Carbohydrate Diet for Obesity — NEJM,” N Engl J Med 2003; 348:2082- 2090. http://www.nejm.org/doi/full/10.1056/NEJMoa022207.


Gosh I remember the feelings I had before I started keto... feelings of fear, feelings of being discouraged or letting myself down again... what if I fail at this like I have with every other thing I’ve tried the past 12 years. Looking back a year ago on Mother’s Day reflecting where I was then to where I am now not just my weight loss but also my mental state at the time. Things were better but I was no where near where I am now. The weight loss and drastically changing my eating habits have all contributed and I’m so thankful I made myself show up everyday. So what if? What if I never gave myself the chance? I preach believing in yourself a lot because you are the only one who can push yourself to make the change. No one else just you. Don’t let the what’s ifs hold you back. Believe in YOU. Show up for YOU. Tip toe if you must but if it’s something you want soooo bad... everyday wake up and TAKE THAT STEP! It’s worth it💕 Happy #transformationtuesday 🌸

I’m discouraged to see that nowhere in the article nor in the comments is there a mention of a diet’s best fit to genetics. Consider if someone is an APOE E2 carrier and/or has certain polymorphisms of the APO5 gene. These are quite rare in Okinawa but much more prevalent in the USA (12% of the population). According to a number of well-designed studies, these genetic characteristics point to a higher fat, lower carbohydrate diet as beneficial and even a “moderate” carb diet as problematic.

It seems obvious that the type of food consumed can affect energy expenditure and fat loss. Staying away from processed foods made with refined starches and added sugar is, “the road map to reducing the obesity epidemic in the United States,” said Dr. Dariush Mozaffarian, a cardiologist and dean of the Friedman School of Nutrition Science and Policy at Tufts University.

But according to the International Society of Sports Nutrition, it won’t. Two groups of resistance-trained and semi-fit men were put on the same training schedule. Half of them followed a 'Western diet' (55% carbs, 25% fat, 20% protein), and the other half followed a keto diet (5% carbs, 75% fat, 20% protein). Both groups consumed the same number of calories. After 11 weeks, not only did participants in the keto group lose more body fat, they also gained more lean muscle mass.
The insulin theory of obesity, in short, declares that the primary cause of obesity is higher carbohydrate diets because these diets increase insulin secretion more than any other diet. When insulin levels are high, fat storage will increase significantly and “starve” muscles and organs of energy.   This causes increased hunger and overeating that results in obesity.
Physician assistants (PA) typically obtain medical histories, perform examinations and procedures, order treatments, diagnose diseases, prescribe medication, order and interpret diagnostic tests, refer patients to specialists as required, and first or second-assist in surgery. Their education includes a bachelor’s degree, extensive clinical training from an accredited PA program and they must obtain a license to practice as a physician assistant.

May help slow tumor growth for certain types of cancer: Early research shows that a calorically-restricted ketogenic diet is an effective alternative therapy for malignant brain cancer (13). Since high levels of circulating glucose in the blood are needed for tumor growth, the glucose-reducing effects of the keto diet help to slow tumor growth (14).
It’s a habit to enjoy a brie cheese for desert instead of a piece of chocolate cake but each are favored deserts in France. I’m personally more satisfied after a 350 calorie sized wedge of brie than the same number of calories of cake.. which will give me sugar crash and .. really I’d like two slices of cake(I’ve got a sweet tooth that once I get going it wants to keep being fed)
In addition, on the day the diet was initiated, diabetes medications were reduced – generally, insulin doses were halved, and sulfonylurea doses were halved or discontinued. Due to the possible diuretic effects of the diet soon after initiation, diuretic medications were discontinued if of low dosage (up to 25 mg of hydrochlorothiazide or 20 mg of furosemide) or halved if of higher dosage. Participants were also instructed to take a standard multivitamin and drink 6–8 glasses of water daily, and were encouraged to exercise aerobically for 30 minutes at least three times per week.

So I have tried many things to loose weight and nothing worked, including this. This was a while ago. Then I decided I was not going to eat breakfast anymore, because in order to loose weight, you need to be a little bit hungry. So anyways, I have been doing intermittent fasting (eating at noon and dinner 6-8) and the first day was hard for me but I stuck to it with the help of some lemon water. The next 3 days became easier and easier. Today, I realized I was not at all hungry for dinner and was a little scared, because I didn’t want my metabolism to slow down (I’ve had problems in the past) so I googled up what this means. I saw that it was ketosis and was so excited. When I went to check the ketosis strips, it was actually working and I was so so happy. The fact that I was trying so hard with all of these fancy recipes and eating 3 meals a day frustrated me. I do not count my calories or anything else. I do some excercise for about 30 minutes everyday. For those who are struggling, please please please! Try intermittent fasting if the ketogenic diet isn’t working for you.
To figure out how many fat grams specifically you want, you would take the total number of calories it takes to maintain your body weight (normally around 14-16 calories per pound of body weight). Subtract your protein calories from that number and then divide by 9 (number of calories per gram of fat). This should give you how many total fat grams you need to eat per day.

The reason why low-carb diets work, according to this theory, is that the lowered levels of insulin (caused by restricting carbs) allow for the body to begin metabolizing fat and increase energy expenditure.   Some proponents of the theory think that the reason restricting carbohydrates works is because of a “metabolic advantage” (i.e., a person on a low carb diet burns more calories than a person eating a diet higher in carbohydrate).

You’ve heard this proclamation even before starting keto diet: You need plenty of water each day for your health. That’s especially true with the keto diet. Without carbs, your body won’t store as much water. Anything you drink passes right through—you can expect to urinate frequently. “Starchy foods have more water retention,” Dr. Marvasti says. “When you avoid these types of foods, you need to make sure you are compensating by drinking enough water.” These 7 clever ways to stay hydrated can help.

7. Raygan, F., Bahmani, F., Kouchaki, E., Aghadavod, E., Sharifi, S., Akbari, E., . . . Asemi, Z. (2016). Comparative effects of carbohydrate versus fat restriction on metabolic profiles, biomarkers of inflammation and oxidative stress in overweight patients with Type 2 diabetic and coronary heart disease: A randomized clinical trial. PMID: 28607566
35. Crujeiras A.B., Gomez-Arbelaez D., Zulet M.A., Carreira M.C., Sajoux I., de Luis D., Castro A.I., Baltar J., Baamonde I., Sueiro A., et al. Plasma FGF21 levels in obese patients undergoing energy-restricted diets or bariatric surgery: A marker of metabolic stress? Int. J. Obes. (Lond.) 2017;41:1570–1578. doi: 10.1038/ijo.2017.138. [PubMed] [CrossRef] [Google Scholar]
Cholesterol serves a number of important roles in the body. First of all, cholesterol is a critical structural element in certain tissues such as our brain and nervous system. In fact, it is estimated that around 25% of our cholesterol can be found in the brain. Just to highlight our failed fat philosophy over the years, higher saturated fat intake and high cholesterol levels are associated with better mental function in old age (1)!
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When your body burns its stores of fat, it can be hard on your kidneys. And starting a ketogenic diet -- or going back to a normal diet afterward -- can be tricky if you’re obese because of other health issues you’re likely to have, like diabetes, a heart condition, or high blood pressure. If you have any of these conditions, make diet changes slowly and only with the guidance of your doctor.

Supporting these results, Naude et al. (15) found a similar outcome in obese adults with and without type 2 diabetes. This meta-analysis of 19 randomized, controlled trials compared dietary interventions using standard CHO recommendation (i.e., 45 – 65%), low-carbohydrate/high protein (LCHP) and low-carbohydrate/high fat (this group, although not specifically stated, met the criteria for KD). Results demonstrated significant weight loss among all groups in the short-term (3 – 6 months) and long-term (1 – 2 years), with no significant difference among dietary interventions. The authors concluded that weight loss interventions using CHO restriction are equally effective as isocaloric diets of standard CHO recommendation.

Ketogenesis has existed as long as humans have. If you eat a very low amount of carbohydrates, you starve your brain of glucose, its main fuel source. Your body still needs fuel to function, so it taps into your reserve of ketones, which are compounds the liver creates from fat when blood insulin is low. This process is known as ketosis: It’s like when a hybrid car runs out of gas and reverts to pure electricity.
The ketogenic diet, or keto, relies on using your fat as fuel, instead of glucose from carbohydrates or protein. Simply put, the daily ketogenic diet consists of 75 percent fat, 20 percent of protein, and a teeny allotment of carbohydrates, about 5 percent. This balance of macronutrients is intended to put your body in a state of ketosis, which suppresses the release of insulin and blood glucose levels. The benefits of ketosis to your health are improvements in biomarkers like blood glucose, reduction of blood pressure and decreased appetite due to fullness linked to consumption of fats.
Note that women with thyroid or adrenal dysregulation require more healthy carbs. In general, the optimal carbohydrate level for you can vary over the years, such as when you’re more active physically or breastfeeding or stressed. Chronically eating low carb may increase your risk of mood disorders, so I urge caution and that you work with your healthcare professional. To be safe, eat the most carbs that you can tolerate while staying in ketosis.
Specific fiber goals for every day will depend on your overall intake, current weight, and weight-loss intentions. Thankfully, some high-fat, low-carb foods are also loaded with fiber. These include nuts and seeds, avocado, and squash. “I see so many clients go for high protein, high saturated fat, and no carb,” says Sunny Brigham, MS, CNS, a board-certified nutrition specialist with a private clinic in North Texas. “They become constipated because they aren’t getting enough fiber.” And that’s just one of the 11 hidden dangers of the keto diet.
“I am an anesthesiologist who managed to lose weight and reverse my pre-diabetes a few years back. I now advocate the low-carb diet and lifestyle to all patients, colleagues and friends. Diet Doctor is a comprehensive one-stop resource which I highly recommend. Almost every patient I anesthetize has metabolic issues, and the situation is difficult as the diet in India is primarily carbohydrate based. I have successfully helped friends and patients reverse their type 2 diabetes.”
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