Thank you for the info.. I have lost 22 lbs in 6 1/2 weeks started Keto on Feb 27, 2019 and today is April 10, 2019..I lose every other day it seems with a couple times that I gained a lb and then lost it the next day.. I IF every couple days to see how long I can go but i do well with one big meal and a small one .or I have a loaded coffee with butter and heavy cream with Stevia in the morning.. I watch everything I can find to help me and I just happened on this.. My body loves me now that I am putting good food in it.. I have so much energy and feel so good.. I am 65 yrs young and want to live a lot longer only better .. Thanks again…
In theory, a ketogenic diet that increases carbohydrate loads for cardio exercise seems perfect. However, the side effects of a ketogenic diet can include dehydration, malnutrition and constipation. According to the Mayo Clinic website, ketogenic plans also can lead to kidney stones. In addition, the ketogenic diet does not give you the nutrition you need to be healthy. Instead, try cutting portion sizes and counting calories; this also can force your body to burn fat while still providing you with balanced nutrition, including proteins, carbohydrates, fiber and fat. As with any diet, you should discuss a ketogenic diet with your doctor.
I think you may be experiencing what I did on an ultra low carb diet. I did try to follow the "20 grams of carbs" approach but it didn't work for me. I felt sluggish, I was tired, and anxious (especially that anxiety!). Having said that, I have Hashimoto's (autoimmune hypothyroid condition) and I can't do very low-carb for that very reason. These days I eat 20-30 grams of net carbs, sometimes up to 50, especially after a workout when my body naturally craves carbs. Keep in mind that some people tend to overemphasise the importance of high ketones while it's not as simple and most people don't even need high ketones: The Ketone Craze - Who Really Benefits From High Ketone Levels? I hope this helps!
The main limitations of our study are its small sample size, short duration, and lack of control group. That the main outcome, hemoglobin A1c, improved significantly despite the small sample size and short duration of follow-up speaks to the dramatic and consistent effect of the LCKD on glycemia. For other effects, however, such as the rises in serum LDL and HDL cholesterol, the small sample size might be the reason statistical significance was not reached. Future studies of larger samples and containing a control group are needed to better address questions about the effect of the LCKD on serum lipids in patients with type 2 diabetes.
“As an interventional pain physician, in addition to cutting-edge techniques I use nutritional strategies to deliver people from a cycle of pain and disability. Chronic pain may result from inflammation and metabolic disarray; it intersects every part of life and is an illness as much as it is a symptom. Obesity and aging are inflammatory processes at the root of many pain-inducing chronic diseases. I suggest anti-inflammatory, low-carb, ketogenic diets and fasting protocols to optimize patients’ health. Diet Doctor is a great resource for patients compliant with this lifestyle.”
Relevantly, a statistically significant decrease was also observed in the craving for specific nutrients from baseline to endpoint (Figure 2B). These modifications in FC-inventory were evidenced from the visit of reduced ketosis as compared with baseline. Whereas, the craving for simple sugars and trans fats was modified earlier than the other items, since maximum ketosis compared with baseline (Figure 2B).
Note: Are you a vegetarian or vegan and want to go on a ketogenic diet? It’s still possible! Just keep in mind that the dietary restrictions can sometimes be a little bit intense. Make sure to plan ahead and prepare to aid your success. To help out, we’ve published articles (with 7 day meal plans included) for both the vegetarian ketogenic diet and the vegan ketogenic diet.
Purnell JQ, Hokanson JE, Marcovina SM, Steffes MW, Cleary PA, Brunzell JD. Effect of excessive weight gain with intensive therapy of type 1 diabetes on lipid levels and blood pressure: results from the DCCT. Diabetes Control and Complications Trial. JAMA. 1998;280:140–146. doi: 10.1001/jama.280.2.140. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
“I follow and recommend a low-carb or keto lifestyle, with and without intermittent fasting, to all of my patients whether or not they have lifestyle-related chronic conditions. I do this because of the health benefits to anyone who follows them, but also because of the science behind them and the impressive clinical results I have seen in my patients. I have recommended the Diet Doctor website for the past 5-6 years as a first-stop to find completely trustworthy information, delicious recipes, great visuals and excellent videos.”

“I have been a UK family doctor since 1990, and discovered the low-carb and keto ways of life in 2014. Until then, I had never seen a way of eating that resulted in normal weight and improvements in other health problems like diabetes, epilepsy, arthritis, and asthma. When I discovered Diet Doctor I was very impressed, and loved the recipes. I now run low-carb courses for the public and health care professionals.”

The primary outcome, hemoglobin A1c, decreased from 7.5 ± 1.4% at baseline to 6.3 ± 1.0% at week 16 (p < 0.001), a 1.2% absolute decrease and a 16% relative decrease (Table ​(Table4).4). All but two participants (n = 19 or 90%) had a decrease in hemoglobin A1c (Figure ​(Figure1).1). The absolute decrease in hemoglobin A1c was at least 1.0% in 11 (52%) participants. The relative decrease in hemoglobin A1c from baseline was greater than 10% in 14 (67%) participants, and greater than 20% in 6 (29%) participants. In regression analyses, the change in hemoglobin A1c was not predicted by the change in body weight, waist circumference, or percent body fat at 16 weeks (all p > 0.05).
d) Or does the entire question revert back to a classic calorie counting exercise? In this case, I’ll eat the minimum amount of protein that is needed to prevent my muscles from being cannibalized (for energy) and for the rest, I’ll limit my dietary fat intake per day to a level, where its energy + energy currently obtained from adipose tissue match my total energy need? (I’ll leave gluconeogenesis out of this equation for simplicity.) If this is the case, I’ll lose adipose tissue, i.e. lose weight, but the interesting question still remains: How much energy can my body extract from the adipose tissue at its best? How can I maximize the share of energy coming from adipose tissue instead of dietary fat? 

I am a tradition Conservative voter, I liked UKIP's common sense policies but worried about the antics of some of its people. If Farage can keep the standard of the Brexit Party candidates up, he's onto a winner from both sides of the traditional party voters. The clueless leftie liberals love to label any party to the right as r4cist, UKIP gave them that excuse, but Farage is clearly not r4cist.

“As a physician, I see daily the tremendous impact that our pandemic of chronic nutritional disease is having on people and the health care system, despite our best conventional efforts over the last 40 years. I now focus my time and energy on counseling, supporting and guiding patients on the power of real food as medicine. Using the core principles of low-carb, high-fat eating and intermittent fasting, we see great improvements in diabetes, obesity, metabolic syndrome, polycystic ovary syndrome, NAFLD and many more chronic diseases. Diet Doctor is a great resource for my patients to help them in their journey.”
If you talk to keto aficionados, you’ll find many save leftovers from dinner for the next day’s lunch. Cook once, eat twice—your keto diet menu for lunch is solved. If you don’t like leftovers or if you’re craving something different for lunch, the mid-day meal can be as simple as a scoop of chicken salad. Or, hit the salad bar at a local grocery store and top a bowl of greens with some good-fat goodies. You can also try one of these simple keto lunches:
Bonnie J. Brehm, Randy J. Seeley, Stephen R. Daniels, and David A. D’Alessio, “A Randomized Trial Comparing a Very Low Carbohydrate Diet and a Calorie-Restricted Low Fat Diet on Body Weight and Cardiovascular Risk Factors in Healthy Women,” The Journal of Clinical Endocrinology & Metabolism: Vol 88, No 4; January 14, 2009.
From baseline to week 16, the mean body weight decreased significantly from 131.4 ± 18.3 kg to 122.7 ± 18.9 kg, BMI decreased from 42.2 ± 5.8 kg/m2 to 39.4 ± 6.0 kg/m2, and waist circumference from 130.0 ± 10.5 cm to 123.3 ± 11.3 cm (Table ​(Table3).3). The percent change in body weight was -6.6%. The mean percent body fat decreased from 40.4 ± 5.8% to 37.0 ± 6.0%. Systolic and diastolic blood pressures did not change significantly over the 16 weeks. The mean heart rate decreased from 81.2 ± 12.9 beats per minute to 74.6 ± 14.0 beats per minute (p = 0.01).

Dear Martina, I wasn’t sure how to contact you. I am a final year undergraduate Human Nutrition student. I was also a keto diet follower and your app and blogs were a great help. For my final year project I‘ve chosen to study the present awareness of the ketogenic diet. I would like to ask if you would be interested to present my questionnaire to your followers. I will of course send you the questionnaire personally first for your approval. Please let me know if you are interested. Thank you for your hard work. You are a great help for many of us.

Functional medicine M.D. Sara Gottfried contributes frequently to goop on the topic of weight-loss resistance. She’s spent the past two years rigorously studying the ketogenic diet—high-fat, low-carb, moderate-protein. Named for ketones, which Gottfried explains are “the energy source made by the body when there’s not enough carbohydrates to be burned for energy demand,” the goal of the diet is to get the body to burn fat instead of sugar.
I wanted to put it out there that I made this meal plan specifically with women in mind. I took an average of about 150 women and what their macros were. The end result was 1600 calories – broken down into 136g of fat, 74g of protein, and 20g net carbs a day. This is all built around a sedentary lifestyle, like most of us live. If you need to increase or decrease calories, you will need to do that on your own terms.
Eating out while going keto can be tricky. Planning ahead helps you know where your next snacks and meals will come from, so you aren’t tempted to reach for an easy—high-carb—fix, like fast food. Each week, plan out everything from meals to snacks and if you’re using an app, go ahead and fill in your estimated macronutrients ahead of time. This will help you get an idea of your overall intake, so you can make adjustments to reach your daily goals more easily. Get started by planning to make these 10 keto recipes so good you’ll never know you’re on a diet.
A survey in 2005 of 88 paediatric neurologists in the US found that 36% regularly prescribed the diet after three or more drugs had failed, 24% occasionally prescribed the diet as a last resort, 24% had only prescribed the diet in a few rare cases, and 16% had never prescribed the diet. Several possible explanations exist for this gap between evidence and clinical practice.[34] One major factor may be the lack of adequately trained dietitians, who are needed to administer a ketogenic diet programme.[31]
Ketosis was determined by measuring ketone bodies, specifically B-hydroxybutyrate (B-OHB), in capillary blood using a portable meter (GlucoMen LX Sensor, A. Menarini Diagnostics, Neuss, Germany) before measurements of anthropometric parameters. As with anthropometric assessments, all of the determinations of capillary ketonemia were made after an overnight fast of 8 to 10 hours. These measurements were performed daily by each patient during the entire VLCK diet, and the corresponding values were reviewed on the machine’s memory by the research team for managing adherence. Additionally, B-OHB levels were determined at each complete visit by the physician in charge of the patient. The measurements reported as “low value” (≤ 0.2 mmol/L) by the meter were assumed to be zero for purposes of statistical analyses.
Low-carbohydrate diets are associated with increased mortality, and they can miss out on the health benefits afforded by high-quality carbohydrate such as is found in legumes including grain legumes or pulses, and fruit and vegetables.[3][4] Disadvantages of the diet might include halitosis, headache and constipation, and in general the potential adverse effects of the diet are under-researched, particularly for more serious possible risks such as for bone health and cancer incidence.[5]

There's a lot of exciting buzz around keto these days, and there's plenty of good reason for it.Ketosis is a natural process the body initiates to help us survive when food intake is low. During this state, your body is actually burning fat for energy instead of carbs. Ketosis is typically extremely hard to obtain on your own and takes weeks to accomplish.
This website is helpful I gained ten pounds just by snacking. I on the Keto diet with 15 carbs a day I stopped all snacking, stopped staying up late because it screws up cortisol / hormones which causes weight gain so I started going to bed at 9:30 on the dot. I typically eat one meal a day a green salad with either, chicken or prawns and simple homemade dressing . Sometimes I do a big glass of a low carb, a chocolate mocha protein drink with a nut milk and ice blended this does the trick. I never eat after 4:00. I have coffee with a little butter and drink lots of water I use Ketostix every other day to see if I’m still in ketosis. I did get foot cramps and increased sea salt intake and it stopped. I love fasting and going to yoga I feel clearer, lighter and just happier. Just keep with a program and you will see light at the end of the tunnel. Some people have great success with zero carbs. I have never tried it but read about it.
The ketone bodies are possibly anticonvulsant; in animal models, acetoacetate and acetone protect against seizures. The ketogenic diet results in adaptive changes to brain energy metabolism that increase the energy reserves; ketone bodies are a more efficient fuel than glucose, and the number of mitochondria is increased. This may help the neurons to remain stable in the face of increased energy demand during a seizure, and may confer a neuroprotective effect.[56]
One downside to a ketogenic diet for weight loss is the difficulty maintaining it. “Studies show that weight loss results from being on a low-carb diet for more than 12 months tend to be the same as being on a normal, healthy diet,” says Mattinson. While you may be eating more satiating fats (like peanut butter, regular butter, or avocado), you’re also way more limited in what’s allowed on the diet, which can make everyday situations, like eating dinner with family or going out with friends, far more difficult. Because people often find it tough to sustain, it’s easy to rely on it as a short-term diet rather than a long-term lifestyle.
While you’re focusing on fat, protein, and carbs, you should also make sure you’re getting adequate fiber. “People often assume that they should only eat things like meat and butter on the ketogenic diet,” says Farshad Fani Marvasti, MD, an associate professor and director of Public Health, Prevention, and Health Promotion at the University of Arizona College of Medicine in Phoenix. “You should make sure you are eating enough vegetables because you need the fiber.”

“I have an interest in diabetes and preventative medicine and have started recommending intermittent fasting in combination with a low-carb, high-fat diet to all of my patients both for treatment and reversal of diabetes and general good health and prevention. I recommend the Diet Doctor website to all of my patients so they can find the best information from knowledgeable experts regarding living a low-carb lifestyle, from educational videos to amazing recipes and everything in between.”
This work was supported by grants from the Fondo de Investigacion Sanitaria, (PI14/01012 and PI17/01167) research projects and CIBERobn (CB06/003), from the Instituto de Salud Carlos III (ISCIII), Fondo Europeo de Desarrollo Regional (FEDER) Spanish. DGA is grateful to the Colombian Department of Science, Technology and Innovation—COLCIENCIAS as a recipient of their pre-doctoral scholarship to support his work. Ana B Crujeiras is funded by a research contract “Miguel Servet” (CP17/00088) from the ISCIII.
From baseline to week 16, the mean body weight decreased significantly from 131.4 ± 18.3 kg to 122.7 ± 18.9 kg, BMI decreased from 42.2 ± 5.8 kg/m2 to 39.4 ± 6.0 kg/m2, and waist circumference from 130.0 ± 10.5 cm to 123.3 ± 11.3 cm (Table ​(Table3).3). The percent change in body weight was -6.6%. The mean percent body fat decreased from 40.4 ± 5.8% to 37.0 ± 6.0%. Systolic and diastolic blood pressures did not change significantly over the 16 weeks. The mean heart rate decreased from 81.2 ± 12.9 beats per minute to 74.6 ± 14.0 beats per minute (p = 0.01).
Patients were invited to complete a battery of psychological tests to assess performance in the domains of food cravings, quality of life (QoL), daytime sleepiness and sleep quality, sexual functioning, and physical activity through the course of the nutritional intervention. The psychological tests were selected for availability of multiple test versions, well-stablished psychometric properties, and accepted clinical use.
MF-BIA (InBody 720; Biospace, Tokyo, Japan) was also used for determining body composition in terms of FM, FM%, FFM, total body water, intra- and extracellular water, skeletal muscle mass, and ASLM. This noninvasive technology employs 8 contact electrodes, which are positioned on the palm and thumb of each hand and on the front part of the feet and on the heels. In addition, MF-BIA uses the body’s electrical properties and the opposition to the flow of an electric current by different body tissues. The analyzer measured resistance at specific frequencies (1, 5, 50, 250, 500, and 1000 kHz) and reactance at specific frequencies (5, 50, and 250 kHz). The participants were examined while lightly dressed, and the examination took less than 2 minutes and required only a standing position. The validity of this technology has been documented in previous studies (21, 22). Visceral fat area values were also calculated in cm2 by MF-BiA. Importantly, these values are significantly correlated with those generated by computed tomography (22, 23). The calculation of the different body compartments was performed according to the instructions of the manufacturer (Biospace).

This book is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits use, duplication, adaptation, distribution, and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, a link is provided to the Creative Commons license, and any changes made are indicated.
Carbohydrate: Most of what determines how ketogenic a diet is will depend on how much carbohydrate is eaten, as well the individual's metabolism and activity level. A diet of less than 50 or 60 grams of net (effective) carbohydrate per day is generally ketogenic. Some sources say to consume no more than 20 grams of carbohydrates per day, while others cite up to 50 grams, and many recommend no more than 5 percent of calories from carbs. However, athletes and people with healthy metabolisms may be able to eat 100 or more grams of net carbohydrate in a day and maintain a desired level of ketosis. At the same time, an older sedentary person with Type 2 diabetes may have to eat less than 30 net grams to achieve the same level.

The reason why low-carb diets work, according to this theory, is that the lowered levels of insulin (caused by restricting carbs) allow for the body to begin metabolizing fat and increase energy expenditure.   Some proponents of the theory think that the reason restricting carbohydrates works is because of a “metabolic advantage” (i.e., a person on a low carb diet burns more calories than a person eating a diet higher in carbohydrate).

Fats: When it comes to types of fat to consume, anything goes. It’s recommended that you consume a mixture of saturated and monounsaturated fats. Things like coconut oil, which contains medium-chain triglycerides (MCTs) help keep ketone levels high. So long as you’re keeping your carbs in check, if you want to go as far as swigging bacon grease to get your fat in, you won’t be the first.

Plagued by pimples? You may start to notice a difference in your skin on the keto diet, especially if you were a former sugar addict. Consuming lots of empty carbs is linked to worse acne—in part because these foods trigger inflammation and signal the release of hormones that up the production of pore-clogging oils, according to a review published in the Journal of the Academy of Nutrition and Dietetics. Some findings suggest that curbing your carb intake could help solve these problems, improving your skin as a result.
If you're new to keto, watch out for hidden carbs. Generally, dairy products and nuts are a good way to meet your daily fat intake, but know that some of those items may contain more carbohydrates than you think. For example, yogurt topped with nuts may seem like a great keto-friendly snack, but a 5.3 ounce serving of plain yogurt has 12 grams of carbohydrates. Vanilla flavored yogurt has 24 grams of carbohydrates. Add an ounce of cashews, weighing in at nearly nine grams of carbs, and you’re up to 21 to 33 grams of carbs for that snack, which could knock you out of ketosis. Be sure to read nutrition labels carefully and pay careful attention to serving sizes. Track foods using a keto-specific app like Senza or KetoDiet can help you stay within your recommended daily carb intake.
The understanding of “What is a Keto Diet” has become blurred thanks to the proliferation of Keto Diet “experts”. Many of these “experts” recommend several variants of Keto Diet and lifestyles which they claim can be modified to any walk of life. However, in most instances what they are actually recommending are Low-Carb lifestyle programs. These are neither weight loss programs, nor Ketogenic. With that said, there’s nothing wrong with adopting a Low-Carb lifestyle, but if your goal is weight loss, then changing your eating lifestyle should come after you’ve achieved your weight loss goals.
Basically, carbohydrates are the primary source of energy production in body tissues. When the body is deprived of carbohydrates due to reducing intake to less than 50g per day, insulin secretion is significantly reduced and the body enters a catabolic state. Glycogen stores deplete, forcing the body to go through certain metabolic changes. Two metabolic processes come into action when there is low carbohydrate availability in body tissues: gluconeogenesis and ketogenesis.[4][5]
Eating out while going keto can be tricky. Planning ahead helps you know where your next snacks and meals will come from, so you aren’t tempted to reach for an easy—high-carb—fix, like fast food. Each week, plan out everything from meals to snacks and if you’re using an app, go ahead and fill in your estimated macronutrients ahead of time. This will help you get an idea of your overall intake, so you can make adjustments to reach your daily goals more easily. Get started by planning to make these 10 keto recipes so good you’ll never know you’re on a diet.
The National Academy of Medicine recommends a minimum intake of 130 g of carbohydrate per day.[23] The FAO and WHO similarly recommend that the majority of dietary energy come from carbohydrates.[24][25] Low-carbohydrate diets are not an option recommended in the 2015-2020 edition of Dietary Guidelines for Americans, which instead recommends a low fat diet.
In 1967, Irwin Stillman published The Doctor's Quick Weight Loss Diet. The "Stillman diet" is a high-protein, low-carbohydrate, and low-fat diet. It is regarded as one of the first low-carbohydrate diets to become popular in the United States.[52] Other low-carbohydrate diets in the 1960s included the Air Force diet[53] and the Drinking Man's Diet.[54] Austrian physician Wolfgang Lutz published his book Leben Ohne Brot (Life Without Bread) in 1967.[55] However, it was not well known in the English-speaking world.
Several recent studies indicate that a low-carbohydrate diet is effective at improving glycemia. A few studies have shown that in non-diabetic individuals, low-carbohydrate diets were more effective than higher carbohydrate diets at improving fasting serum glucose [13,14] and insulin [6,14-16], and at improving insulin sensitivity as measured by the homeostasis model [6]. One of these studies also included diabetic patients and noted a comparative improvement in hemoglobin A1c after 6 months (low fat diet: 0.0 ± 1.0%; low carbohydrate diet: -0.6 ± 1.2%, p = 0.06) [6] and 12 months (low fat diet: -0.1 ± 1.6%; low carbohydrate diet: -0.7 ± 1.0%, p = 0.019) duration [5]. In a 5-week crossover feeding study, 8 men with type 2 diabetes had greater improvement in fasting glucose, 24-hour glucose area-under-the-curve (AUC), 24-hour insulin AUC, and glycohemoglobin while on the low-carbohydrate diet than when on a eucaloric low-fat diet [7]. In a 14-day inpatient feeding study, 10 participants with type 2 diabetes experienced improvements in hemoglobin A1c and insulin sensitivity as measured by the euglycemic hyperinsulinemic clamp method [8]. Hemoglobin A1c also improved in an outpatient study of 16 participants who followed a 20% carbohydrate diet for 24 weeks [9].
“That means you’ll eat avocado, coconut oil, meat, and cream of coconut, olives, and olive oil, animal fats like bacon or chicken fat, butter, fatty cuts of meat, fatty fish like salmon and sardines, as well as nuts and seeds,” Mancinelli says. Dairy is allowed on keto, she adds, but it has to be heavy cream. Milk, even full-fat, isn’t keto-approved.

From an outpatient clinic, we recruited 28 overweight participants with type 2 diabetes for a 16-week single-arm pilot diet intervention trial. We provided LCKD counseling, with an initial goal of <20 g carbohydrate/day, while reducing diabetes medication dosages at diet initiation. Participants returned every other week for measurements, counseling, and further medication adjustment. The primary outcome was hemoglobin A1c.
The ketogenic diet may seem like the Jekyll to the Hyde-like low-fat craze of the 1990s. The bulk of current research finds that the middle ground between the two extremes is more beneficial for overall health. Make it easy for yourself: Eat at least two servings a week of fatty fish (salmon, sardines, mackerel) and cook with a variety of quality fats (olive oil, canola oil, avocado oil) throughout the week.
When in the hospital, glucose levels are checked several times daily and the patient is monitored for signs of symptomatic ketosis (which can be treated with a small quantity of orange juice). Lack of energy and lethargy are common, but disappear within two weeks.[17] The parents attend classes over the first three full days, which cover nutrition, managing the diet, preparing meals, avoiding sugar, and handling illness.[19] The level of parental education and commitment required is higher than with medication.[44]
I think Tammy is asking about labeling on products. I have also found the percentages to be inconsistent. I think it is due to the way they companies calculate the grams in relation to the average daily intake- the result being different as the range  goes from 225-325 grams per day. At the end of the day the company decides how they calculate the percentage so the best way to solve this is to look at the grams instead.
“After struggling with weight my entire life, I was pointed in the direction of a low-carb diet by a group of other physicians — and it changed my life. As a family physician, it became clear to me how many of my patients could benefit from this lifestyle in so many ways. I spent time training with other doctors who had been practicing nutritional medicine with their patients for years, and learned how best to help my own patients. This is my passion, and being able to help change patients lives in this way is incredibly rewarding.”
Katherine Arvesen, RDN, who in private practice in Plano, Texas, also notes that the study was not randomized and controlled, which is the gold standard for medical research to minimize error and bias. In this study, the patients were their own controls, meaning their results were compared with their own baseline (starting) measurements, not with the results of a control group.
The weight-loss program has five steps and adheres to the most recent guidelines of the 2015 EFSA on total carbohydrate intake [22]. The first three steps consist of a VLCK diet (600–800 kcal/day), low in carbohydrates (<50 g daily from vegetables), and lipids (only 10 g of olive oil per day). The amount of high biological-value proteins ranged between 0.8 and 1.2 g per each kg of ideal body weight to ensure that patients were meeting their minimum body requirements and to prevent the loss of lean mass. In step 1, the patients ate high-biological-value protein preparations five times a day and vegetables with low glycemic indexes. In step 2, one of the protein servings was substituted with a natural protein (e.g., meat or fish) either at lunch or at dinner. In step 3, a second serving of low-fat natural protein was substituted for the second serving of biological protein preparation. Throughout these ketogenic phases, supplements of vitamins and minerals, such as K, Na, Mg, Ca, and omega-3 fatty acids, were provided in accordance with international recommendations [23]. These three steps were maintained until the patient lost the target amount of weight, ideally 80%. Hence, the ketogenic steps were variable in time depending on the individual and the weight-loss target. The total ketosis state lasted for 60–90 days only.