The ketogenic diet is usually initiated in combination with the patient's existing anticonvulsant regimen, though patients may be weaned off anticonvulsants if the diet is successful. Some evidence of synergistic benefits is seen when the diet is combined with the vagus nerve stimulator or with the drug zonisamide, and that the diet may be less successful in children receiving phenobarbital.
8. Van Lenten, B. J., Hama, S. Y., De Beer, F. C., Stafforini, D. M., McIntyre, T. M., Prescott, S. M., … Navab, M. (1995). Anti-inflammatory HDL becomes pro-inflammatory during the acute phase response. Loss of protective effect of HDL against LDL oxidation in aortic wall cell cocultures. Journal of Clinical Investigation, 96(6), 2758–2767. PMID: 8675645
Note: Are you a vegetarian or vegan and want to go on a ketogenic diet? It’s still possible! Just keep in mind that the dietary restrictions can sometimes be a little bit intense. Make sure to plan ahead and prepare to aid your success. To help out, we’ve published articles (with 7 day meal plans included) for both the vegetarian ketogenic diet and the vegan ketogenic diet.
So rather than giving one-size-fits-all dietary advice or weaponizing the word “balanced” it might be better if the medical community suggested that there are Individual differences that need to be considered. This might also help those lay folk who have had success with one dietary lifestyle or another also realize that what’s valid for them may not be good advice for others.
“The growing scientific evidence is robust that the low-carb, ketogenic diet is safe and effective, especially for the management and reversal of type 2 diabetes and for weight loss. I believe that millions of people in the world might have their health improve by adopting this way of eating. Together with the growing team at Diet Doctor we aim to make low carb simple and to empower people, everywhere, to revolutionize their health. Having so many respected low-carb doctors join this page helps spread the word about this potentially life-changing way of eating.”
Coconut oil has been denounced “officially” by the American Heart Association and others who parrot “authoritative” nutritional advice condemning saturated fats despite the overwhelming independent science that prove they’re wrong about fats. (See: Coconut Oil is Beneficial for Your Heart: Shining the Truth on Mainstream Media’s Negative Attacks Against Coconut Oil.)
“As a Diplomate of the American Board of Clinical Lipidology, I help my patients decrease their risk of diabetes, heart disease, stroke, and Alzheimer’s disease. Intermittent fasting, low-carb, high-fat (LCHF) diets, and ketogenic diets have powerful effects on adiposopathy, arterial inflammation, and endothelial dysfunction. Patients often come to me for a consultation because they have developed an extremely high LDL-P while on a ketogenic diet. We work together to improve their lipid profile by optimizing their nutrition and lifestyle using a personalized, integrative approach.”
Epilepsy is one of the most common neurological disorders after stroke, and affects around 50 million people worldwide. It is diagnosed in a person having recurrent, unprovoked seizures. These occur when cortical neurons fire excessively, hypersynchronously, or both, leading to temporary disruption of normal brain function. This might affect, for example, the muscles, the senses, consciousness, or a combination. A seizure can be focal (confined to one part of the brain) or generalised (spread widely throughout the brain and leading to a loss of consciousness). Epilepsy can occur for a variety of reasons; some forms have been classified into epileptic syndromes, most of which begin in childhood. Epilepsy is considered refractory (not yielding to treatment) when two or three anticonvulsant drugs have failed to control it. About 60% of patients achieve control of their epilepsy with the first drug they use, whereas around 30% do not achieve control with drugs. When drugs fail, other options include epilepsy surgery, vagus nerve stimulation, and the ketogenic diet.
Prior to the advent of exogenous insulin for the treatment of diabetes mellitus in the 1920's, the mainstay of therapy was dietary modification. Diet recommendations in that era were aimed at controlling glycemia (actually, glycosuria) and were dramatically different from current low-fat, high-carbohydrate dietary recommendations for patients with diabetes [1,2]. For example, the Dr. Elliot Joslin Diabetic Diet in 1923 consisted of "meats, poultry, game, fish, clear soups, gelatin, eggs, butter, olive oil, coffee, tea" and contained approximately 5% of energy from carbohydrates, 20% from protein, and 75% from fat . A similar diet was advocated by Dr. Frederick Allen of the same era .
“After years of practicing Family & Sports Medicine, I’ve recognized that preventing and addressing my patients’ dietary metabolic issues are the foundation upon which quality medical and musculoskeletal care are built. LCHF principles produced such remarkable results in my patients that I completely redefined my scope of practice and developed a unique Lifestyle Medicine Program that synergistically complements my Sports Medicine & Non-Surgical Orthopedics specialty practice. I truly care for the whole person. Diet Doctor is an exceptional, comprehensive resource for lay persons and clinicians; I recommend it to all my patients and colleagues.”
4. Gomez-Arbelaez D., Bellido D., Castro A.I., Ordonez-Mayan L., Carreira J., Galban C., Martinez-Olmos M.A., Crujeiras A.B., Sajoux I., Casanueva F.F. Body composition changes after very-low-calorie ketogenic diet in obesity evaluated by 3 standardized methods. J. Clin. Endocrinol. Metab. 2017;102:488–498. doi: 10.1210/jc.2016-2385. [PubMed] [CrossRef] [Google Scholar]
While body weight decreased significantly (-8.5 kg) in these 21 diabetic participants, the mean weight loss was less compared with what we observed in the LCKD participants of an earlier trial (-12.0 kg) . Given that the diabetic participants had a higher baseline mean weight than the LCKD participants of our previous trial (131 kg vs. 97 kg), this translates into an even more dramatic disparity in percent change in body weight (-6.6% vs. -12.9%). This lesser weight loss might result from several factors. First, in the current study, most of the participants were taking insulin and/or oral hypoglycemic agents that are known to induce weight gain[20,21] Second, these same agents, particularly insulin, inhibit ketosis, which is strived for in the earliest phases of the LCKD; while it remains unclear whether ketones actually play a role in weight loss on the LCKD, previous research in non-diabetic patients has shown a positive correlation between level of ketonuria and weight loss success . Lastly, compared with our previous study the participants in the current study had more comorbid illness, lower socioeconomic status, and a shorter duration of follow-up (16 weeks versus 24 weeks), all of which are associated with reduced success on any weight loss program .
51. Sarwer D.B., Spitzer J.C., Wadden T.A., Rosen R.C., Mitchell J.E., Lancaster K., Courcoulas A., Gourash W., Christian N.J. Sexual functioning and sex hormones in persons with extreme obesity and seeking surgical and nonsurgical weight loss. Surg. Obes. Relat. Dis. 2013;9:997–1007. doi: 10.1016/j.soard.2013.07.003. [PMC free article] [PubMed] [CrossRef] [Google Scholar]
If you talk to keto aficionados, you’ll find many save leftovers from dinner for the next day’s lunch. Cook once, eat twice—your keto diet menu for lunch is solved. If you don’t like leftovers or if you’re craving something different for lunch, the mid-day meal can be as simple as a scoop of chicken salad. Or, hit the salad bar at a local grocery store and top a bowl of greens with some good-fat goodies. You can also try one of these simple keto lunches:
The data are presented as mean (standard deviation). All statistical analyses were carried out using Stata statistical software, version 12.0 (Stata, College Station, TX). A P < 0.05 was considered statistically significant. Changes in the different variables of interest from baseline and throughout the study visits were analyzed following a repeated measures design. A repeated measures analysis of variance test was used to evaluate differences between different measurement times, followed by post hoc analysis with Tukey’s adjustment for multiple comparisons. In addition, linear regression analyses were used to evaluate the accuracy of MF-BIA and ADP in comparison with DXA, because DXA is considered the reference technique in the estimation of body composition in clinical research (26). Finally, the Bland-Altman approach was also used to assess the accuracy of MF-BIA and ADP against DXA in the estimation of FM%.
Ketones are generally an efficient source of fuel for your human body. They're created the fatty acids in your liver; a consequence of the breakdown of fatty tissue. These only appear when there's a lack of glucose and sugar. Inside Atkins diet plan, you reduce the amount of glucose and sugar that may be from the bloodstream. Hence, your system produces ketones for fuel. When your system is creating ketones it is known as ketosis.
The good news, however, is that following a well-formulated ketogenic diet should help increase HDL while lowering triglyceride levels. LDL will likely remain the same or potentially increase in order to efficiently transport triglycerides to cells to metabolize for energy. Again, LDL will likely become more of the pattern A type which is a highly beneficial shift.
Effect of the nutritional intervention with a very low-calorie-ketogenic diet on physical activity pattern (A) and sleep disturbances (B). Data represent mean ± standard error of changes from baseline. (ƚ) Denotes statistically significant differences through the intervention (p for trend < 0.05) evaluated by means of repeated-measures ANOVA. (*) Denotes statistically significant differences (p < 0.05) from baseline after post-hoc pairwise comparisons employing the Tukey’s adjustment for multiple comparisons. IPQA, International Physical Activity Questionnaire.
Table 2 contains the correlation matrix that assessed the association between the changes in the physical and psychological states. Many relevant R-coefficients were found, confirming that changes in body composition (BMI, FM, FFM, and weight) and ketosis were strongly related to the differences in food craving, alcohol craving, sleep patterns, physical activity, and sexual activity. These associations emerged when changes between baseline and maximum ketosis were assessed, and they remained quite similar for changes estimated between baseline and reduced ketosis or endpoint. Regarding the ketosis change levels, associations emerged with some subscales in all the psychological questionnaires, except for the FCI scales and the multidimensional alcohol craving measures.
In this section you’ll find the original set of 12 weeks of Keto Menu Plans that thousands and thousands of people have used to lose up to 50 pounds or more on the Keto Diet! Easy and delicious recipes, shopping lists and prep lists to make your transition into keto foolproof and effective! You can use an app to input the data if you want to track your macros, but honestly if you’re following these plans closely you shouldn’t need to!
There are so many tricks, shortcuts, and gimmicks out there on achieving optimal ketosis – I’d suggest you don’t bother with any of that. Optimal ketosis can be accomplished through dietary nutrition alone (aka just eating food). You shouldn’t need a magic pill to do it. Just stay strict, remain vigilant, and be focused on recording what you eat (to make sure your carb and protein intake are correct).
“I recommend low-carbohydrate, high-fat (ketogenic) diets to almost all my patients to improve their quality of life. The LCHF diet reduces inflammation, promotes weight loss, and improves blood biomarkers without prescription agents. The result is improved sleep, sharper mental clarity, more energy throughout the day, and healthier relationships to food. Most patients suffer “fat phobia” but fat does not make you fat! Sugar does! We teach patients to eat lots of healthy fats and cycle in and out of ketosis. We refer everyone to Diet Doctor as a great resource, especially for the carb contents of various food and drinks.”
The insulin theory of obesity, in short, declares that the primary cause of obesity is higher carbohydrate diets because these diets increase insulin secretion more than any other diet. When insulin levels are high, fat storage will increase significantly and “starve” muscles and organs of energy. This causes increased hunger and overeating that results in obesity.
Gary D. Foster, Ph.D., Holly R. Wyatt, M.D., James O. Hill, Ph.D., Brian G. McGuckin, Ed.M., Carrie Brill, B.S., B. Selma Mohammed, M.D., Ph.D., Philippe O. Szapary, M.D., Daniel J. Rader, M.D., Joel S. Edman, D.Sc., and Samuel Klein, M.D., “A Randomized Trial of a Low-Carbohydrate Diet for Obesity — NEJM,” N Engl J Med 2003; 348:2082- 2090. http://www.nejm.org/doi/full/10.1056/NEJMoa022207.
Keto is a healthy state for some, but not all. It is most proven for epilepsy and other brain problems like Alzheimer’s, mild cognitive impairment, and Parkinson’s disease. There are more safety concerns for people trying keto for fat loss or performance. In humans, there are reports of adverse reactions to keto, including menstrual irregularities, gut dysbiosis, change in circadian rhythm, hair loss, constipation, mood disorders, and thyroid dysfunction; and in rodents, insulin resistance and nonalcoholic fatty liver.
"Obese. That's what the doc said. He said if I didn't change I'd be Morbidly Obese. So stopped eating big macs and started out by walking. But it wasn't really enough to undo the damage. Then I found on Shark Tank. So I found it online and ordered it. I figured, it was worth a shot. I'm glad I did. It jumpstarted my weight loss! I started shedding the weight. I'm down 60 pounds after just 9 months! Thank you - you really saved my life!"
The accurate measurement of body composition changes is relevant to assess the contribution of the diet intervention, not only to total body weight but to the changes produced in FM, FFM, visceral fat tissue, and total body water (25, 27). To obtain such information, multicompartmental models that integrate information obtained from a single measurement (body density, total mineral mass, total body water) may be used to reduce the number of assumptions made on the stability of body characteristics (28). These models are of limited application in clinical practice, because they do not provide immediate results, are expensive, and require advanced analytical expertise (29, 30). For such reasons the 3 more widely used body composition analysis techniques were used in the present work. DXA is the most validated and commonly used technique to analyze body composition in obese patients and is based on the attenuation of a low-energy X-ray beam, depending on the tissue density and chemical composition. DXA is considered the gold standard technique by most groups working with body composition and was used as the reference method in the present work. Bioelectrical impedance techniques are low cost and readily available and rely on the use of population-specific equations to assess intracellular and extracellular water distribution. The MF-BIA system used in this study is a recently developed version that is not based on statistical population data and is capable of accurately assessing subjects with different body shapes and also obese subjects. Finally, ADP measures body density and is used more easily than other more complex systems for measuring body density, such as underwater weighing, and provides comparable results for obese subjects. Therefore, the use of 3 validated methods that use different principles was relevant for evaluating patients in different stages of a body weight reduction program.
I believe you’re “breaking your fast” by having Olive oil in the morning. Anything over 5 calories will cause an insulin spike. I’ve been intermittent fasting (IF) 16:8 for 4 months and have just recently moved to try ketosis. I’m exercising in a fasted state. I lost 7kg of fat. Can’t comment on how effective Keto is yet, my understanding is it’s excellent for optimal fat burning.
The inclusion criteria were age 18 to 65 years, body mass index (BMI) ≥ 30 kg/m2, stable body weight in the previous 3 months, a desire to lose weight, and a history of failed dietary efforts. The main exclusion criteria were thyroid alteration, diabetes mellitus, obesity induced by other endocrine disorders or by drugs, and participation in any active weight-loss program in the previous 3 months. In addition, those patients with previous bariatric surgery, known or suspected abuse of narcotics or alcohol, severe depression or any other psychiatric disease, severe hepatic insufficiency, any type of renal insufficiency or gouts episodes, nephrolithiasis, neoplasia, previous events of cardiovascular or cerebrovascular disease, uncontrolled hypertension, orthostatic hypotension, and hydroelectrolytic or electrocardiographic alterations were excluded. Females who were pregnant, breastfeeding, or intending to become pregnant and those with child-bearing potential and not using adequate contraceptive methods were also excluded. Apart from obesity and metabolic syndrome, participants were generally healthy individuals. Under these conditions, 20 obese patients were included in this study.
A cyclic ketogenic diet (or carb-cycling) is a low-carbohydrate diet with intermittent periods of high or moderate carbohydrate consumption. This is a form of the general ketogenic diet that is used as a way to maximize fat loss while maintaining the ability to perform high-intensity exercise. A ketogenic diet limits the number of grams of carbohydrate the dieter may eat, which may be anywhere between 0 and 50g per day. The remainder of the caloric intake must come primarily from fat sources and protein sources in order to maintain ketosis (the condition in which the body burns fats and uses ketones instead of glucose for fuel).
Hi Barb, That can definitely be it. Losing when you are close to goal can be more difficult. It could also be that your body’s healthy weight is a little higher than what you’d like – which doesn’t mean you can’t lose, but makes it more difficult. If just eating Keto foods isn’t working, double check the macros for your weight and see if the amount you’re eating needs to be adjusted. You’ll find more help and support in our support group here.
Keto Shop and the parent brand KetoGenics™ was developed with the needs of the low carb, ketogenic community in mind. In addition, those who follow Intermittent Fasting will also benefit from our products. More products are being added to the KetoGenics™ line up on a monthly or semi-monthly bases so please be sure to check back often. Future products will include a small to moderate line of supplements tailored to those who follow a low carb, ketogenic lifestyle. In addition to low carb support, there will also be supportive supplements for those who follow an Intermittent Fasting eating regimen.
I actually went on a ketogenic diet last year to see if it would help my migraines. I have a history of chronic migraines which would usually last 3 days, sometimes longer. Triptans help a lot but I don’t like having to take them. I stayed in ketosis for about 8 months and experienced a significant reduction in migraines, from feeling some type of headache (mild o r severe) almost everyday to 1 or 2x per month while in ketosis. Although I’m very healthy otherwise, I do think my migraines may have something to do with blood sugar fluctuations (despite previously eating a whole foods diet and no refined carbs), and keto totally stabilized this. I eventually came off of Keto because I’m not really a meat lover. When I came off, but remained low carb, my migraines stayed under control for the most part. When I increase carbs, they do return.
The ketogenic diet is used to treat drug-resistant childhood epilepsy. It has become a fad diet for people attempting to lose weight. Dieters trying this often do not achieve true ketosis as this requires extreme carbohydrate restriction, and maintaining a ketogenic diet is difficult. Some diet advocates make misleading claims that the ketogenic diet can treat or prevent cancer.
In the 1960s, medium-chain triglycerides (MCTs) were found to produce more ketone bodies per unit of energy than normal dietary fats (which are mostly long-chain triglycerides). MCTs are more efficiently absorbed and are rapidly transported to the liver via the hepatic portal system rather than the lymphatic system. The severe carbohydrate restrictions of the classic ketogenic diet made it difficult for parents to produce palatable meals that their children would tolerate. In 1971, Peter Huttenlocher devised a ketogenic diet where about 60% of the calories came from the MCT oil, and this allowed more protein and up to three times as much carbohydrate as the classic ketogenic diet. The oil was mixed with at least twice its volume of skimmed milk, chilled, and sipped during the meal or incorporated into food. He tested it on 12 children and adolescents with intractable seizures. Most children improved in both seizure control and alertness, results that were similar to the classic ketogenic diet. Gastrointestinal upset was a problem, which led one patient to abandon the diet, but meals were easier to prepare and better accepted by the children. The MCT diet replaced the classic ketogenic diet in many hospitals, though some devised diets that were a combination of the two.
A very recent review on nutritional approaches toward preventing and reversing Alzheimer’s disease (AD) was conducted in Christchurch, New Zealand’s Canterbury University. The results were submitted to the journal Nutrition. It’s title: "The ketogenic diet as a potential treatment and prevention strategy for Alzheimer's disease." After analyzing 33 studies researching AD and other neurological disorders handled with a ketogenic diet and supplementing coconut oil, the University of Canterbury review analysis concluded: "In this review, we hypothesize that the ketogenic diet could be an effective treatment and prevention for Alzheimer's disease, but both ketone production and carbohydrate restriction may be needed to achieve this."
The average person's diet contain about 55% carbohydrates, 30% fat, and 15% protein. On the keto diet, you eat a whole lot more fat, and a lot less carbs: 80% of the diet is comprised of fat, 15% is protein, and a mere 5% of calories come from carbohydrates. For someone on a 1,500-calorie diet, that translates to 19 grams of carbohydrates per day, which is less than what you find in one medium-sized apple.
High-fat dairy also contains high-quality protein, vitamins, minerals, and conjugated linoleic acid (one of the few fatty acids that have been found to promote fat loss). The combination of these nutrients is essential for maintaining strength and function as we age. By adding just 7 ounces of ricotta cheese to their daily diet, for example, the older participants of a recent study were able to increase their muscle mass and muscle strength. In other words, ask for extra cheese, please.
But what about body fat? Hall and Guo investigated 20 controlled feeding studies that reported changes in body fatness on equal-calorie diets differing in fat and carbohydrate content. They found that each diet has similar effects on body fatness, which makes sense when you consider the finding that neither diet provides a significant metabolic advantage. (Yet higher-carbohydrate diets seem to cause a slightly more substantial loss of body fat per calorie — a 16 gram per day difference.)
The Bulletproof Diet (download the roadmap for free here) counters these side effects by keeping protein levels even lower. It is a cyclical ketogenic diet, which means you eat keto for 5-6 days a week and then do a weekly protein fast, which lowers inflammation and kickstarts fat-burning. This is much better for your body and spurs weight loss even more. The Bulletproof Diet also involves a carb re-feed day, where you eat slightly more carbs than usual. Since keto diets mimic starvation, you want to make sure your body knows that food isn’t scarce (this is especially important for women trying to conceive).